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That's really interesting, thanks. Perhaps someone should make a separate thread on this? There are multiple ways to identify ME/CFS patients in the UK biobank as explained here: Defining a High-Quality Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cohort in UK Biobank - PMC Looks like...

Older study from 2007, some quotes that might be relevant to ME/CFS research:

Abstract Whereas biomedical products are required to be tested for safety with respect to vulnerable organ systems, psychosocial treatments are not required to be tested for safety with respect to vulnerable social systems such as the family. This article provides some evidence for the need to...

As I understand it, the consortium leaders are the problem. Think there was some reasonable biomedical research under this project but wonder how those researchers think about the statements by Liira that they pretty much found nothing. That didn't sound very respectful. It's not that you'll...

You can find that progress report on this page: https://cordis.europa.eu/project/id/101057553/results Decision support for prediction and management of Long Covid Syndrome (LCS) -> Results -> Deliverables -> Documents, reports (12) -> Results of the AIR trial.

No the progress report was submitted to the EU last year already. I just had a closer look at it following the protest and then the statements made in the article in L'Express.

True, but it sounds as if they themselves think the results won't change and the control group is doing slightly better on each of these preliminary outcomes. Found it remarkable given that the consortium leaders were arguing that biological studies only lead to null results and that a...

Agree, confirmed in this trial registration and supplementary material of the protocol. https://clinicaltrials.gov/study/NCT05212467 But it's strange that this study on Long Covid is doing a large trial that includes other patients as well (fibromyalgia prevalence is like 2-4%). The EU grant...

Looks like the authors shared preliminary results in this document to the EU (see attachment). There were no significant group differences for the three main outcomes. This is from a preliminary analysis that includes only 215 out of necessary 270 patients but the report writes that "there is...

Looks like this is funded by the EU grant on Long Covid: Here's the link to the EU page on the project which received 6.5 million in funding. Decision support for prediction and management of Long Covid Syndrome (LCS) | Long Covid | Project | Fact Sheet | HORIZON | CORDIS | European Commission...

Thanks @forestglip Used AI to screen these genes on function and these two might be interesting: ITGAE - facilitates adhesion of T-lymphocytes to epithelial cell TECPR2 - aids in the formation of autophagosomes

Made this summary of the paper: 1) Trigger warning: suicide This paper analyzed 505 entries on the National CFIDS Foundation memorial list. These were people with ME/CFS who passed away. The messages summarize their life, illness and struggles. The researchers grouped these into several...

Thanks for doing this. One issue I see is that we don't have a standardized measure of effect size to filter these. I suspect that in a lot of the things that come up like smoking, overall health and cognitive tests, the DNA has only very minor effects and that they only come up because these...

It seems that in this study the authors pre-selected only 22 traits because they have previously been implicated in ME/CFS and the brain/synapses was not included. The full list is in table 1 in the online methods. Most did not reach high correlations. Migraine and IBS were already known to be...

Anyone has any updates on this? No update or changes on the journal website yet from what I can see https://onlinelibrary.wiley.com/doi/10.1002/hbm.70505

Another paper on this for those interested: Link: https://pubmed.ncbi.nlm.nih.gov/11705431/

An addditional study by these authors, this time using GP records in 11 practices in Devon, UK. They found that CFS patients had more GP consultations for various complaints in the 15 years before their diagnosis than controls with MS. This could point that CFS patients were never truly...

Excellent blog, clearly written, thanks! Perhaps not very relevant but Jason also looked at seasonal onset in his Chicago cohort and found significantly more cases where onset was in January compared to other months. Seems likely to be due to chance in my opinion (it had a low sample size of...

Found this old 2001 paper on Chiari malformation surgery in fibromyalgia and CFS Can fibromyalgia and chronic fatigue syndrome be cured by surgery?

Older 2-day CPET studies such as the one by Davenport also used the Fukuda criteria so that alone likely wouldn't explain the results. Severe ME/CFS patients can't do these test so highly likely that these were mild-moderate patients just like in previous 2-day CPET studies. The idea was that...