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Guest blog by Professor Chris Ponting and colleagues at ME/CFS Research Review UK Biobank - a national biobank different from the ME/CFS biobank - has data from around 500,000 individuals, including both healthy people and those with one or more of the many different diseases in the UK...

I didn't know that. But presumably it's still a sign of immune action? Earlier during the Stanford symposium, Mark Davis showed clonal expansion in CD4 cells for colon carcinoma taken from diseased tissue vs no expansion in adjacent healthy tissue. But I think the MS results were from blood...

Chris Ponting will be at the event (he’s based at Edinburgh University).

Sorry, my comment wasn't very clear. I really shouldn't post before I'm awake. The OMF review on 25 May said: The "click here" details. Looking again at that, they are taking 25 patients and Many studies have highlighted issues with the immune system in ME/CFS, ranging from altered...

Mark Davies is trying to find the antigen that he believes has set of the clonal expansion. That could identify if this is autoimmunity or driven by a particular pathogen. So if that checks eggs then it could lead to targeting the pathogen/autoimmunity and say potentially lead to a cure. That’s...

Glad you liked it! Because the technology is still being developed, there isnt an exact timetable for when it will be up and running in this project. But if Chris manages to recruit a suitable candidate to start this autumn, the new technology could be being used late 2019 running into 2020...

Full blog A team led by Edinburgh University’s Professor Chris Ponting has won funding for a PhD student who would follow up and expand on remarkable recent findings made at Stanford University where Dr Mark Davis may have pinpointed a major issue in the immune system in ME/CFS. Last year...

The biology behind the study The aim of the PhD is to build on Mark Davis's work, which indicated that for mecfs the problem with the immune system could be T-cell clonal expansion. T cells are cousins of antibody producing B cells. And just as antibodies have very specific binding, so too do...

A bit of background Me too. The study came about after I mentioned Mark Davis's work on T cells to Chris. I thought that was one of the most promising findings I'd ever seen. From my blog on the work: Look at that difference! Chris also thought it was exciting and important. I hadn't expected...

New biomedical research PhD launched in Scotland https://www.actionforme.org.uk/news/new-biomedical-research-phd-launched-in-scotland/ Action for M.E. and the Scottish Government’s Chief Scientist’s Office are delighted to announce the recipient of our jointly funded PhD studentship in...

A non-technical perspective: When I tried the Stroop test, I found it incredibly hard. My brain was totally focused on that and nothing else. Sure, I wasn’t in an MRI scanner, but I don’t think that would’ve made any difference. My brain had no spare capacity for anything beyond the test...

id meant that as May 2018, but see it’s unclear. Now May 8 Thanks. I’d originally had “Massive Siri had Knesset!) $86 million shop full”. Then I took out the figure because it’s too precise. The hundred million dollars is just an estimate. Basically, current funding is an order of magnitude less...

One for ME Awareness week There’s a yawning gap in ME/CFS research funding. Take action. When I got ME more than 20 years ago, I thought that science would soon provide the answers to my illness. Instead, I saw little good research going on, and there’s been a spectacular lack of progress...

It’s a Q&A. Chris is suggesting there is currently rather more to it than that.

Thanks for the explanation, @Woolie I write a blog about cognitive tests and fatigue a few years ago: http://phoenixrising.me/archives/16688 I can’t remember all the details of the research, but I think the Stroop test is one of those that has shown differences between patients and controls...

Very kind :). I did write the piece in part to give people hope, but mainly because I feel very hopeful myself about the collaboratives. I’ve long been frustrated by the general lack of high-quality biomedical research and I really do think that the collaboratives are going to change that in a...

A new research landscape emerges in America Things are changing in the US for ME/CFS research as four new collaboratives set up and get to work. In September last year, the National Institutes of Health (NIH) announced $35 million of funding to establish three new ME/CFS research...

I’m not sure I actually count as a “proper expert”, but here goes: That video was pretty detailed. But the principle of how AMPK operates is pretty simple. Its senses the energy state of the cell, and when the cell starts to run low on fuel AMPK responds by boosting energy production, and...

Goodbye, Bob. Will miss you so much. I’m thinking of you, and your family.

Authors: Jose G Montoya1, Jill N Anderson1, Danya L Adolphs2, Lucinda Bateman3, Nancy Klimas4, Susan M Levine5, Donn W Garvert1, Jon D Kaiser this was a double blind multi-centre trial (n=67 + 68) of a mitochondrial-function boosting treatment, using the Checklist individual Strength...