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Recommended by Hutan Ubiquitin proteasome pathway

Recommended by @jnmaciuch https://aklectures.com/ and their YouTube channel https://m.youtube.com/@AKLECTURES Immune system playlist https://m.youtube.com/playlist?list=PL9jo2wQj1WCNaYmBK_B81PlrX4OYLwb13

Thanks @jnmaciuch those videos look like a handy resource. And @Sasha I’m sure we’ll all discuss and help each other along the path of understanding as we always do :)

Everything… ok I shall continue with my crash course in blaggers biology then :)

Any suggestions on topics for background reading/learning for those of us not versed in this stuff who want to have the best chance of understanding what you’ll be talking about? DecodeME got me learning about DNA. This paper built on that with B cell repertoires, receptors and lifecycles as...

A correction to this has been published https://link.springer.com/article/10.1007/s00431-025-06112-w

There’s some info in a methods section in the supplementary sections (search for Stanford ME/CFS cohort) Stanford was diagnosis by specialist clinicians in the Bay Area using ICC and IOM criteria CureME they don’t mention criteria directly (but as you say we know) Stanford they say the group...

Sorry about that, I messed up the first link. Fixed now The DOI link doesn’t seem to be working, but is as quoted in the citations, so will leave it and hope it starts to work at some point…

Immunotherapies for Postural Orthostatic Tachycardia Syndrome, Other Common Autonomic Disorders and Long COVID: Current State and Future Direction Blitshteyn, S., Funez-dePagnier, G., Szombathy, A., & Hutchinson, M Abstract Postural orthostatic tachycardia syndrome (POTS), neurocardiogenic...

I think Mario was referring to o3 reasoning, one of the newer models from OpenAI.

A couple of other bits I found useful: HEAL stands for “hierarchical estimate from agnostic learning” (I found the older paper useful in understanding the background to this updated framework) Video on the STRING database I also have some AI generated summaries of the papers and comparisons of...

Basic process seems to be fairly common ML.. - Get a good dataset, filter out similarities from other reasons like being related - Train a network on this dataset, the idea being you know the inputs and output and are searching for what commonalities may exist in the data - Once trained use his...

More info on their previous HEAL model in this paper https://pubmed.ncbi.nlm.nih.gov/30193110/ And on the STRING database used for protein protein interaction networks https://pubmed.ncbi.nlm.nih.gov/36370105/ I’d definitely be interested in those who understand this properly giving some...

Mixed methods study of views and experience of non-hospitalised individuals with long COVID of using pacing interventions Christel McMullan, Shamil Haroon, Grace Turner, Olalekan Lee Aiyegbusi, Sarah E Hughes, Sarah Flanagan, Anuradhaa Subramanian, Krishnarajah Nirantharakumar, Elin Haf...

This popped up in my google scholar alerts too, due to the mention of ME/CFS, which from their definition I’m not convinced the author understands particularly well. I don’t think they're trying to dismiss it, just don’t understand it. There’s acknowledgment of people not being believed etc...

It does sound great, both what they’re doing here and what you describe Kitty. Adding an air to air heat pump and some solar panels would be a great way to ensure heat in the winter and cooling in the summer too. I’ve often dreamt of a bungalow like that. Somewhere I could even get outside of...

I can’t say I’ve been able to keep up with the biology of this all, but have certainly found it interesting and thought provoking. Thanks everyone. There’s certain ways I’ve thought about aspects of this that have been challenged and other new thoughts introduced. I’m no clearer on what is...

It was weird when ME/CFS started appearing in my dreams. And sometimes it’s there and sometimes not. I can dream and be aware of my ME/CFS or not at first so be running or cycling and suddenly go ‘wait I shouldn’t be able to do this’ or it can not pop up at all, which is obviously a lovely...

Nice work Team France :thumbup:

Thanks for the tips. I will be getting some more earplugs soon so will report back. For the daytime when it's noisy I am similar to @Evergreen in a multiple step approach. I have in ear headphones with comply foam tips which isolate well and then ear defenders over the top, then play music or...