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Understood @jnmaciuch I look forward to hearing if/when you have something more to share :)

I saw this pop up in my alerts and thought the same so gave up. My chain of thought went “heart rate analysis looks interesting, is this a paper or something else, experimental poetry, what?” Grain is a literary magazine in Canada.

I’d echo that. Or post threads using threadreader or something without any barriers? I haven’t been on twitter for many years and won’t be signing up just to read things as you seem to need to do these days.

This would be funny if it wasn’t so pathetic. It’s sentiment analysis on twitter, lol. Not going to waste any energy reading or thinking about it. I will add they used RoBERTa for the sentiment analysis, this is an old and small mode based on Google’s BERT. Maybe it’s good in specific...

Are you thinking generally @jnmaciuch or that this is an issue in specific places? Say, issues around degradation of neurotransmitters or other proteins by the proteasome around the synapse?

I’ve wondered that. There seems to be at least a genetic predisposition. Could there be a natural development towards it to? Perhaps with people pushed over an edge by an illness if not that illness being a trigger as has often been seen? I suppose some comes down to how you define these things...

This from another thread but… I was listening to descriptions of neurotransmitters and receptors and this was said Which seemed relevant here, with different people having different effects of drugs, varying symptoms etc. With a neuron having both excitatory and inhibitory receptors, perhaps...

The platform SequenceME are hoping to use seems to do methylation detection I think. Oxford Nanpore had a conference this week and mentioned it along with other improvements to their platform, I caught some bits of announcements from it, but am not sure of all the details. relevant posts on...

With my new found knowledge of what a glial cell is (okay only roughly, at least I know different types exist) I have a question… Which type of glial cell are you thinking of here or more generally with the glial activation idea?

Understandable. I’m sure we all have this concern to varying degrees. There are various things they could and probably will try. But it’s good we have the environment here and some good scientists with which we can explore it. And ultimately I think we’re best served by getting on with good...

Lol, true, and can you imagine how much your jaw would ache after chewing gum? Chewing. For pleasure. Madness!

Definitely does do for me. Everything becomes too much input! What others too have described, does remind me of what it was like early on for me, when I could still watch films, play games etc but within a limit. And it was perhaps more about fatiguability. All beyond me now. But equally I’m...

It is worth contacting them https://www.decodeme.org.uk/faqs/can-i-change-my-consent-choices/

Some of the symptoms for us seem to be the body trying to respond to whatever underlying problem exists. At least that’s what it sometimes feels like. That could explain the paradoxical nature? I also had a period of quite severe depression in my late teens (at least partially triggered by...

Different types of neurons and glial cells? What even are they? And how do synapses work? What is a synaptic cleft and action potential? I’ve found the Khan Academy videos and text particularly useful (partially mentioned above) all covering roughly the same information with some variation...

My point is about the use dehumanising language particularly on top misunderstandings of other people and in this case cultures and countries. As soon as you take a disagreement and instead dismiss because others are not or are less than human I am concerned we are slipping into dangerous...

The paper focuses on the genes which may be involved. But the model uses knowledge of protein interactions too. I wonder if it’s possible to get details of which protein interactions were deemed to be important. Can the network be examined to pull out these? I think the paper talks about modules...

Maybe we should focus on critiques of content rather than questioning if people are or are not people?

It may be worth seeing my question and Andy’s response in the Zhang paper thread too.

Since this has come up a couple of times now. And it’s a very fair counter to my original comment of there being no damage, it is uncertain. However… Do we know if this damage is common? Do we know if any damage is causative of symptoms? Or the result or byproduct of them? Or even unrelated? I...