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interesting bit: Seems to happen a lot in the psyc papers I read. And this: Old timers will remember that one example of those "red flags" offered in that 2016 paper was vexatious CFS patients with an anti-science agenda.

Nice points, @strategist!

:rofl::rofl::rofl::rofl:!!!!

It was an interesting article, raising all sorts of questions about whether off-label use of antidepressants is good or not. My impression on reading the article was that there seemed to be a lot of different claims being made about a lot of different medicines. And they couldn't all be right...

Yes, sure. I should first say what my main sleep problem was: waking in the middle of the night. Usually hot and fluey. It would take hours to cool down enough to get back to sleep, and if I didn't get enough sleep before morning, I'd be in much more pain during the day. I now take half a...

That's an interesting thought, @Samuel. I just read over that other thread where you posted, and it seems to be presenting the opposite view from mine. That you focus on a core set of symptoms and assume any others are coincidental. But maybe not as different when you look more closely? What...

Oh gosh, look at all the psychologisation in this article, I didn't notice it first read. They could be talking about ME patients, the language is so similar: That last one is of course somatisation. This is exactly what many think is the cause of ME.

Oh, I see. Although there's no suggestion that every case of sleep disturbance is due to atrophy. Or even most cases. Just some. Sorry you've had no joy with sleep meds :(. I've found a happy combination that works well for me, and that has really made a difference to my life.

@Little Bluestem, if its any reassurance, the article is actually suggesting the opposite. That the brain atrophy causes the sleep problems, not that the sleep problems cause the atrophy. But not getting good sleep in general is a worry, I feel the same way too. There's quite a lot to be said...

This is a really good article. Not trying to be sensationalist or to arouse panic, just stating that adverse events reporting in drug trials is not as good as we think it is. I thought this line was terribly astute - and it reminded me of what happened in the PACE trial. Edit: I tend to think...

Yea, that's interesting. They love to capitalise on the government's desire to save money, don't they?

Wow, sort of self-contradictory, isn't it? On the one hand, we shouldn't be bothering our doctors with our health questions. On the other, we shouldn't be trying to answer those questions ourselves either. Well, which is it? Should we try to get some useful information ourselves? Or rush...

Good question. None of my doctors has commented and I haven't asked (who even knows how seriously they took the ME diagnosis in the first place?). But I know what I think. All my symptoms - past and present - seem consistent with my new diagnosis. So yes, I suppose I never had "ME". But then...

@Josie, that's a really low dose of hydrocortisone, so I wouldn't expect it to give you a great deal of relief. Interesting that it gives you some, though. Just to give you a point of comparison: When in a bad crash, I used to get some relief from 40mg of prednisone daily, which is roughly...

Go @mayadusenbery! Thanks so much for your work.

Just thought I'd share this. My immunologist (who seems to really know his stuff) has just prescribed Zantac for me. I thought, "That's weird, isn't that for gastric problems?". Well, apparently, only recently, Zantac was discovered to be an IL6 (interleukin 6) inhibitor. IL6 is the cytokine...

Interesting, @Alvin. Though its hard to know what to make of it. I think the type of tasks they're using to measure memory involve a lot of different skills, so its unclear to me whether this is really about memory, or about the effect of good sleep on cognitive function more generally. There's...

Glad you're not too much the worse for wear, @Binkie4. Thanks for the good tips - although the one about being open about ME might not work so well in some environments!

I don't know much about RFCBT. But the models of depression on which mainstream CBT for depression is based - like the Beck model in all its incarnations - continue to attribute a central role to negative thoughts and rumination in particular. People sometimes assume that CBT is...

Please do be a devil's advocate!:devilish:;) Its much more fun when we're arguing from different points of view. You're right. And self-rated pain scores would be fine in a fully blinded study, like a drug study, because then they can't be biased by participants' expectations. The problem is...