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There is a lot going on in this paper. Tthe authors performed metabolomics pre/post exercise in addition to more specific analysis of gut antigens. While things certainly seemed different in the GI, I'm not sure what exactly they would tell us, and I'm not sure how meaningful some of the...

One question I had at the start, was there a need to "get this out there" on twitter and naturally generate social media hype. I think the answer to that is pretty uniformly "no" and in retrospect does not benefit the me/cfs community. I think that colors the situation quite badly.

Serpina5 came up in a multi-omics paper on long covid. And here in a genetic evaluation in me/cfs.

Interesting paper, I've read about half of it. The authors are from Newcastle University, and aim to test if any of a slew of neurological tests can indicate which of 5 potential hypothesized pathologies of fatigue would apply to Long Covid patients (6-26 weeks after infection, average fatigue...

My experience has been that a clinician will start with the bio-social and leave out the psychology at first, at least directly, and then add that element in. In practice, this ends up sounding it does here, me/cfs as a lifestyle illness. Which is offensive by itself.

Just because it's a top clinic doesn't mean their understanding of me/cfs is superior. (e.g. mayo clinic) Pretty much every point you mentioned is a red flag. Mayo also told their patients similar recovery rates. ME/CFS isn't caused by lowered adrenaline and noradrenaline. Metaphrines? All I get...

Thanks for listening. I saw it and kind of avoided it. Starting with a personal, BPS anecdote is exactly the kind of thing that will stick in people's mind and be a deciding take on the condition. I was a bit thinking that's the underlying take the Economist and it's subsidiaries would have. I...

Maybe some side-effects popped up and they couldn't justify moving forward. It's use in me/cfs seemed hugely speculative, I'm not sure what the expectation are/were.

As someone who has not followed Systrom's work closely, how accurate is the statement from OMF: My understanding, which may be incorrect, was that the 2-day CPET results were an oddity in me/cfs, but maybe not unique to it. I was unaware of the claim that 2-day CPET can identify PEM or...

I have mentioned before biopsy studies would be interesting to me, and I was optimistic for the Harvard OMF's study before Tompkins passing. As he was uniquely qualified I don't know what will happen there. There have been quite a few studies imaging the brain, and many of them have been...

Well, surely he had no preconceived notions going in! His response to legitimate criticism of his article will undoubtedly be to claim he is under-attack and being harassed. We should have the NIH apology for that made up claim by a BPS researchers show up where the Newspaper is made up...

This paper is interesting, the findings of increase in ANG-1 and P-SEL are large in the long covid cohort vs others with no overlap. I don't know how meaningful grouping 14 factors together is, but AUC=1 is quite good, no? I don't know how frequently the ANG-1/P-SEL factors are tested for, but...

I was only able to get through the first half of the methods paper, but this at least looks like more thorough and earnest attempt from a group I don't know about (in spain). Criteria was ICC from a single referral clinic in Barcelona. One important note is the authors say none of the controls...

Bateman is coauthor in some of the Cortene studies, I don't know the extent of the relationship. I believe she supplied some patients so that may be where some of this stress response narrative is coming from. The diagram does indeed seem quite silly, I think you could create about 100 ones that...

Still waiting on anything published, other than a PEM survey, on the me/cfs study that started before covid-19 was around. Is it a Nath thing or NIH thing? What a disaster. So they just halted it to slowly churn through post-covid and throw steriods and IVIG at 12 patients. I don't know if I...

Interesting. It looks like a good attempt from the authors, but I didn't read the paper in depth; there is a helpful infographic following the abstract for anyone who can't read the entire paper. Fatigue is also analyzed as an outcome in the supplementary material but I wasn't sure how to read...

Iirc Ron Davis said he found higher omega3s in me/cfs patients but postulated it was due to supplementation. Think it was in a video.

I remember this from when they started because of how atypical the cohort was, and therefore a stretch to connect it to me/cfs. This is@Forbin 's quoting Nath during an NIH call.

There is this paper by the Griffith University group that may be relevant to "Intra-brainstem connectivity is impaired in Chronic Fatigue Syndrome", but it uses the Fukuda criteria. These papers might ahve some useful figures for you, it's beyond my knowledge base tbh...