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I guess that's good he's still looking about different types of traps. Chris Armstrong is also looking at "nitrogen trap".

I really like Warren Tate, and I like the idea behind this paper even if I didn't follow all of the methylation discussion. The choice for the terms "recovery" and "relapse" seems really poor, the author's use them to describe variations or changes in health status rather than indicative of...

Long way to go from that to this tiny study. There was overlap between NO levels in vitro anyway, although they results were pretty interesting, so, I'm not sure NO alone is the explanation. If it was replicated, whatever is causing low NO would likely be involved in other things as well. It did...

It's hard to say since I couldn't read the whole Lancet article. You'd assume that NICE would be pretty annoyed by that and PG's tweets. It's an attack on the integrity of NICE maybe even more so than the me/cfs community.

Corrupt? As in, when the NICE resignations took place, and one of the resigners happened to work in the same building in the same University of Paul Garner and the BMJ happened to interview not an me/cfs researcher, not a clinician but PG? Just a remarkable, unrelated happenstance. Is defending...

Yeah, I think my comment was unfair even with context. I can see the value in a "practice run" for safety, dosage, and I guess if I put my cynicism aside, timetable as the authors are doing here. Sometimes these papers can feel like they are made just to maintain a research cycle rather than for...

No controls, why bother?

On the me/cfs subreddit for the past month or so there have been a number of reports of moderate improvements from high dose thiamine. Normally I would ignore this, but the number did intrigue me. Not a rec just an observation.

I've been thinking about a paper I read and realized I'd dismissed findings like this Because self-reported onset seemed unreliable. However, with COVID-19 this problem is ameliorated as many, especially later on in the pandemic can verify infection type, severity and mostly the exact...

This looks like well intentioned research. The kind we hoped would shed light on post viral syndromes. However, probably due to practical problems like age-control matching and total control numbers, it's not particularly convincing. Some interesting results anyway The section I bolded piqued...

Cannabis, the SSRI and maybe a few others look likely to show some benefit although we all know the limits of this stuff. LDN/Niacin, Boswellia/Curcumin/VC are also well known. I've heard about larazotide acetate for a while for various GI ailments, althought it seems that's not what it's being...

I finally have gotten down to the original paper. What can you say about representative slides? The cohorts had dramatic gender differences, most importantly the long covid group is large majority female while acute covid is majority male. So even the objective serum measures are hard to...

I hadn't realized just how problematic this paper was. It looks like the finding of 'micro-clotting' is not even exclusive to long covid, but a result of trawling in various diseases, like diabetes, parkinsons and dementia. The results section doesn't make it clear but I believe their is no...

I have mixed feeling on the OMF. I have so many questions - where is the metabolomics replication, why has the nanoneedle not been tested in other diseases, what progress has been made to uncover (something in the blood). I understand good science takes times, but many of the questions are going...

This is a version of long-covid that seems a long way off from what we call me/cfs I have to say I'm confused by the lattice network, it's not intuitive just looking at the chart, so I'll just refer to the statement. Hence why I'm hesitant to celebrate the influx of a long-covid research as...

I can't say specifically much about any concept like - and especially in this paper - the leaky gut problems (which seems to be a crushingly important health issue in the occasional paper and then never show up again, surely we can determine if we're all walking around poisoned by LPS bacteria?)...

Sounds sketchy. YIKES. Seems like they are pushing, and likely charging, for as many "programs" as possible.

What is interesting is that none of the me/cfs patients were above the average score for the test for controls even though the average difference was only 2/5 vs 3/5. You can try the test online, although it does indeed look nightmarish for a person with me/cfs. The problem with these test is I...

At least in my case, pain and fatigue can have a negative effect on appetite. Google suggests that's not uncommon but I suspect it can also have the opposite effect in some individuals. It can also be as simple as not able to go to the grocery store as often.

The differences were way more dramatic than I was expecting - levels of dopamine and niacin were about half that of the controls. I do wonder about diet, maybe overall food intake is lower in fibro. But, still I was not expecting that. The authors discuss fibro in the context of central...