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I think the dropouts may have been higher in that group but can't remember. The other thing is the GET group could be fitter rather than better making it a little easier to walk - I believe walking was the main exercise. The differences weren't great.

I have come across a couple of people who have recovered but I suspect that is a post viral thing (one was ill for a couple of years). One of the things I think happens is as people start to feel a bit better they try stuff to improve and then the credit things tried with further improvements...

This did make me wonder if the test that McLaren Howard is doing is in some way different but perhaps not well documented within his protocol that Tomas tried to follow.

It is a little more complex than that because they are not looking for numbers but whether there was a significant difference between groups. So it may be like saying there are more tall men than women in a group. This is likely to be true if you choose 6ft as a tall threshold but if you choose...

There reasoning for doing the change was not well justified so it demonstrates a willingness to tinker with the reporting without good reason. I don't think the CRQ scores really have much meaning. Its a fairly random set of questions with some being about physical fatigue slightly less about...

I think an analysis that was done on the Fine data showed that the trial changed from having a non-significant result to a significant one when they did this. The PACE team may have been aware of this when they were writing their stats plan.

We should remember they are different scoring schemes in that there are patients that improved with one scheme and got worse with the other. When there was this effect it was often they improved on the likert scale and got worse on the binomial one. In the main paper they gave a reason for...

From their response https://www.drmyhill.co.uk/wiki/Response_to_the_paper_%27Assessing_cellular_energy_dysfunction_in_CFS/ME_using_a_commercially_available_laboratory_test%27_by_Cara_Tomas_et_al This worries me in terms of the suggestion that the test needs to be done 4 times due to a high...

I'm not convinced by the line they draw it could be more like clusters with severe, less severe (and healthy) (where 4 is an overlap) and this could represent the difficulty in getting and sending blood samples.

Unblinding is the formal process where they look at the data or associate treatment labels with the data (I think they may have prepared summary stats for the data management committee). It doesn't mean that they couldn't have a good guess at what was happening. They were set up to have good...

They should be embarassed about some of their claims around data management which suggest that QMUL is simply not fit to run a trial. There are levels of data management that you would not expect a professional organization to fall below and from what I can see they fell below these levels. But...

They admit in the main pace paper that the normal ranges used in the recovery paper were adhoc. From the minutes to the PACE committee meetings it is unclear how the changes were made and who if anyone actually approved them or realized they happened beyond having a stats plan. They dropped...

There is a calculation spreadsheet for some different countries for the EQ5d scale https://www.economicsnetwork.ac.uk/health/EQ_5D_index_calculator.xls I think the quoted values are using the TTO scale.

But they were struggling to convert from Stata formats even though its very easy and there are plenty of examples of how to convert in places like stack exchange. Its they way they suggest the data sets are huge when they are quite small. You don't need a server cluster to perform analytics on...

A pro science stance needs to be done from the perspective of understanding science and methodology not just supporting the 'right people'. I'm not a fan of Myhill as I think others aren't. Worth pointing out that Horton (lancet editor - although I could have got the name wrong) was a supporter...

It is such a poor questionnaire that it doesn't need a research project to say that.

I don't think that the analogy is a good one (and not good for computers either). At the hardware layer what we really have is a series of transistors (and other electrical components). A chip is made up of transistors which are arranged in a particular way to compute a given function (or...

I think I have written complaints in the past and not got a response but they do claim to read them all.

I sent it on Sunday 28th and got the response on Friday. I tried to just keep to one main point to get it under 500 words rather than cover everything that was wrong

I sent a complaint to the Guardian and got this reply from the readers editor Here was my complaint (which they limit to 500 words).