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No control group, useless. Double-blind trials of antidepressants typically show huge placebo effects.

Do these pop-ups vary by region? When I search chronic fatigue syndrome, I get: and it directs you to the CDC website. Under Medication tab, there's nothing about antidepressants, just quotes NHS:

Good to see long-term follow-up and this dramatic clinical improvement from a bedridden state and unable to lift his arms above his head to:

This study from 2016 in SS, did it actually pan out in the end? 8 years is a long time. This paper has few citations, mostly some crappy reviews, so I presume no one in rheumatology is taking this very seriously. The problem with citing primary literature in medicine is that most findings turn...

Bizarre conclusions. The symptoms reported by patients in questionnaires may be caused by a totally different mechanism that has nothing to do with autonomic dysfunction.

Papers show that GPCR receptor autoantibodies occur in similar concentrations in ME/CFS patients and healthy controls, with a very large overlap in distributions. Therefore, they are not causing the disease. This was explained on another thread very recently.

That paper analysed baseline data as far as I can tell.

Trial protocol here: https://classic.clinicaltrials.gov/ProvidedDocs/36/NCT01650636/Prot_SAP_000.pdf

If this is a secondary analysis, is there a paper describing the analysis of primary endpoint? The way they’re slicing and dicing the sample in an arbitrary way and looking at interactions makes me think the primary endpoint was negative.

My hopes for this are very low, especially given the six month delay.

I've also had various experiences of abrupt major improvement which make me rule out various hypotheses involving muscle pathology etc. On the rare occasion when I get a cold, my energy levels improve noticeably in the first day or two, then crash back to Usual Shitty Baseline combined with...

Those POTS exercise trials are of the same methodological quality as PACE and they also have huge dropout rates.

Every quack says the same thing about his quack therapies.

New CAR-T case report from China, this time in a patient with Sjögren's and lymphoma. https://www.frontiersin.org/articles/10.3389/fimmu.2023.1298815/full

That’s quite a leap. Anyway, the metabolic changes observed here are very similar to those reported in obesity studies. What they inadvertently looked at here is the effect of a hypercaloric diet.

Not sure why the poster on Twitter is saying the participants didn’t develop ME/CFS. I skimmed through the paper and I don’t see where they assessed if participants developed clinical symptoms of PEM, fatigue, cog dysfunction etc.

Funny how they have no problem dishing it out and ruining our lives with their writings but a little bit of heat comes their way on Twitter and they run away from confrontation.

Nah. Some trial protocols are flawed and need to be changed during a trial. There is nothing unethical per se about a protocol amendment. The issue here is that they knew what treatment everyone was on, they saw that the treatments weren’t working and they made protocol changes to rescue their...

He's also defending the protocol changes because they were done prior to statistical analysis. Of course, in a double-blind trial that would be fine, but in an open-label study you know what way the results are heading so it's indefensible.

FND physiotherapist shares his thoughts on the PACE trial. Lower down in the thread he mentions that 50% of his FND patients have PEM. https://x.com/zacharygrindpt/status/1747017130673938641