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Full data for what? The reanalysis is based on the original dataset which NIMH handed over.

Yes, the 35% remission rate includes passage of time, regression toward the mean, “placebo effect” and various biases. As there was no placebo control group, we have no idea how the 35% remission rate compares to doing nothing or howling at the moon or taking a sugar pill.

Raters were blinded and were administering the Hamilton Depression Rating Scale. These blinded ratings were supposed to be used as the primary outcome. However, the investigators switched to an unblinded self-rated scale in their trial report. There was no placebo control group and the patients...

The largest and most impactful trial of depression of all time has now been reanalysed using individual participant data obtained from the NIMH. The STAR*D trial was originally published in the American Journal of Psychiatry in 2006 and has amassed over 5,000 citations. It cost the US taxpayers...

Great letter @rvallee

Horrifying.

Who is he to make that determination that your life is shit? My life pre-ME/CFS wasn’t great by any means but it was my life and I’d like it back. The only life I get was robbed from me by this stupid illness.

If they believed their own findings, they would. Instead we have this ridiculous paper with 14 ME/CFS patients and controls of no description.

Ummm, what? No it doesn’t.

They get combined if deemed similar enough.

No

IPD meta analysis just means analysing individual participant data from original studies (pooling them all together) instead of the usual meta-analytic approach of using summary data from published studies (eg means, standard deviations) to pool the results of many studies. It can’t overcome the...

They’ve been going on about this IPD meta analysis of exercise since we were still on the other forum. It’s going to suffer from the same methodological issues as conventional meta analysis based on summary data. IPD makes no difference. I’d say they’ll probably just submit it to a regular...

I’d say they probably sent this to the BMJ first and got fobbed off so they ended up in JNNP. It’s a good journal but it doesn’t have the same wide readership or impact.

There are no treatments, let alone personalised treatments.

Most of these would get FND on their chart.

So many powerful posts on this thread. I can definitely relate to this feeling of catastrophic loss or absence of personality. Most days I feel utterly disconnected from the rest of the world, as if I'm not a real person. I absolutely dread socialising or even workplace conversations. Other...

There’s an urgent need to stop publishing crappy reviews calling for more crappy studies. I had high hopes for this before I read the conclusion. I thought someone was finally taking on the cult of toxic positivity.

This sounds worth following up on. I’m surprised that this lab is doing N=15 studies considering how well funded they are.

The point is that this is mainstream technology accepted in mainstream medicine, not some highly speculative fringe science paper. If what he says is true, and remember he first published these results many years ago when we were still on the previous forum (the initial paper on unexplained...