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From what I gather, if the victim has an MD after their name, then their postviral syndrome is real and needs urgent NIH funding. If the victim is just some pleb, then that person has a psychosomatic issue and needs a gym membership.

Yes but if people are saying they are getting positive effects from 0.2 mg and such microdoses, assuming those effects are real, then they can also get harmed by the same dose. Published literature is irrelevant.

As an infectious disease doc I imagine she has seen PVFS and ME/CFS patients in her career. Based on her statements here about exercise, she probably fobbed them off with terrible advice and now that she has PEM herself she still doesn’t grasp what’s going on, she is still dismissing others...

Wine and cider particularly bad. Beer I don’t know, rarely drink it. Spirits least bad, esp. the expensive stuff.

In the early years of ME even two glasses of wine would make me feel completely drunk and sick for days afterwards. I was mildly ill at the time and still working full time and socialising a few times a year (with great difficulty). I live in a country that has a serious problem with heavy...

I’m amazed that the Oxford vaccine hasn’t been scrapped given the much better alternatives available. I guess the Covid panic has overridden capacity for rational/critical thought in the medical establishment and govt, if they had any to begin with. The Lancet paper was full of protocol changes...

I’ve been given both G93.3 and R53 by different doctors and in both cases it was heavily implied that this is a post viral fatigue syndrome and dysautonomia and that the symptoms are psychosomatic and would probably resolve in six months. WHO classifications are largely irrelevant, used mostly...

Useful study, glad to see this published. No evidence of hysteria here but it doesn't sound like it was ME/CFS either, unless I am missing something. It sounds like for most people it was a self-limiting postviral fatigue syndrome.

Good questions. I don't think nutrition plays a role here. To alter the kynurenine pathway you'd would need to be on a weird mix of amino acids which you can't achieve eating normal food. Most people in those studies are probably eating something more or less akin to the standard Western diet...

Forgive my scepticism, but if that ends up being the case, it would be, to my knowledge, the first known instance of a psychiatric drug being disease-modifying in a true sense, in any condition. They all mask the symptoms. Some would argue that long-term pharmacotherapy with psychotropic drugs...

Could you say more about what’s wrong with their understanding of effort? If you feel up to it of course.

It should be easy enough to do an RCT of this. Widely available drug, no travel to infusion centre necessary unlike in the rituximab trial etc. @J.G I didn’t say the two drugs had the same mechanism of action. I was discussing dopaminergic interventions (including diet) more broadly. Years...

Abstract The importance of tryptophan as a precursor for neuroactive compounds has long been acknowledged. The metabolism of tryptophan along the kynurenine pathway and its involvement in mental disorders is an emerging area in psychiatry. We performed a meta-analysis to examine the...

Yeah. We can't paint these treatments with too broad a brush. While there are some commonalities like altering relevant neurotransmitters, aripiprazole is obviously much more selective in what you're trying to target. Something like keto on the other hand results in profound shifts in energy...

I would be cautious about dopaminergic drugs in ME/CFS. I think these approaches just mask the symptoms while the underlying disease process is still there and possibly getting worse while you are overexerting without the warning signal of PEM. A friend of mine who has had ME/CFS for 40+ years...

"The majority of patients (n= 25, 89%) were taught to correct respiratory CO2 levels during a single biofeedback training session." And? Did it cure them? :rolleyes:

For fuck's sake.

If deconditioning doesn’t cause ME/CFS, what possible reason is there to push, I’m sorry, encourage, the patient to increase their activity level? Who says it’s possible to increase activity level? As others have said, this is an obvious rhetorical shift to save their jobs. That’s the problem...

Sad state of affairs. No ideas, no clues - nothing.

When the very first posts started appearing on forums about CCI, my gut reaction was that this would end up being a bigger public relations disaster for us than XMRV. Everything that's happened since has only reaffirmed my view on this. Ironically, this sort of "advocacy" will ultimately...