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Aren't many of us forum members in some way conspiracists? And EBM hasn't always been good to us, or reliable. I think that's where the merits of discussion come in.

I'm not sure why on a gut level I find this position worrisome, but I do.

As I think you know, channelopathies might qualify.

My n=1 tale is sleep doesn't help, even a good sleep doesn't help, but a bad sleep, i.e., worse than typical, can make things decidedly worse.

BTW, one of the reasons I think DecodeME has merit is the seeming relevance of the 80/20 rule in both Long Covid and Lyme. Is there a significant minority of the population that find it more difficult to clear pathogens due to genetics?

I'm sorry, I'm not following you. What theory? Lyme is tissue-tropic. That's not a theory. PCR tests for agents - or their remnants' - DNA, hence it's a direct test of sorts. It's typically employed in serum draws, so the DNA needs to be in the blood. None of that is theory. It may be helpful...

But it doesn't, much in the same way that saying we cannot find the spirochete in direct testing in most cases after the bull's-eye doesn't. PCR is a direct test, usually used in blood serology, and Bb flees blood first chance it gets. I don't believe that for a nano-second. This appears to be...

Not necessarily. Look at the NIH's definition of genetic predisposition: https://www.cancer.gov/publications/dictionaries/genetics-dictionary/def/genetic-predisposition Whenever lifestyle emerges as a supposed factor, the cork is out of the bottle. Not trying to be negative, just looking at...

Human nature. Agreed. Nor do they over the pathogen by which they are infected. Perhaps it's just a pick your own poison. If I were directing monies I'd prioritize new and better diagnostics for herpes variants and enteroviruses and tick-borne diseases, etc. Or the opposite could happen if no...

The simpler take-away is a PCR is lacking as a diagnostic when a given pathogen flees blood. Yeah, this would be a dangerous association regardless of the infection being researched. Genes don't cause Lyme disease; a spirochete does.

So I am well aware I lack clarity. But if ME/CFS is caused by any persistent infection, isn't perfecting diagnostics more important than seeing if a certain gene variation leaves someone more susceptible to a pathogen? Yes, that's a big if, but so is assuming there is a genetic role here. We...

Yes, what is the CDC doing? And the NIH? Another OspA vaccine. It may not be a bad idea for someone considering taking a new vaccine to find out what happened with the first almost 25 years ago. Do the research as opposed to letting questionable sources do it for one.

Seems more prudent to focus on determining the cause(s) of any disease or syndrome, rather than some purported innate deficiency that may or may not be responsible for the disease presenting faster or worse in a portion of the patient population.

Good point. In the US, which tests for "Lyme & other-tickborne infections" are: a) unquestionable, and b) not private? Also, I'm unclear whether, when you write "misdiagnosed", that would include undiagnosed.

All-in-all, pretty good. About time. But the post-infection/post-injury section, towards the end, with its reference to a "hunkering down" mechanism, left me scratching my head and feeling concerned - almost as if we'd played a good game, but ended with an own goal.

Yes. That is not necessarily the same thing as labeling different types of fatigue. I fear that may prove to be the endpoint of efforts such as this.

Is it though? Or is it semantics and connotation/denotation masquerading as science? Are there different types of nausea? Or, instead, varying degrees and causes? Ultimately, isn't nausea a downstream effect? I worry the fatigue thing is a forever stretching, winding dead-end, deflecting our...

"Resting" in the conventional sense is not an appropriate word for us, as well. There is an implied sense of recovery in the word "rest". We don't recover; we just try to stop before we make ourselves worse. At best, we stop because we can do no more. But there is little in the way of recovery...

What's relapsed Lyme disease? 30,000+ cases of Lyme disease per year? It's widely accepted it's at least ten fold that figure. How odd.

We shouldn't lose sight of who it is that is whispering into Nath's ear.