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CD 57 abnormalities are not restricted to Lyme, so it reduces this metric utility. This is like CXCL13 in CSF of Lyme patients: there seems to be a coorelation, but it's not proven to be specific to Lyme.

A couple of observations: First, chronic Lyme is a poisoned diagnosis. Discard it. The question is does a patient have Lyme disease. Second, the Western Blot and the C6 and other ELISA's only test for exposure. That's it. It is very very rare to know if a patient's Lyme is active or not...

They'd have to show something on their labs. If their labs show nothing suggestive of Lyme exposure, then imo they should not be diagnosed with Lyme. Too many other possible culprits should go into the differential diagnosis. In the UK the C6 is the lab of choice by the NHS. I prefer the...