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    Multi-ancestry GWAS of [LC] identifies immune-related loci and etiological links to [CFS], fibromyalgia and depression, 2024, Chaudhary et al

    The day is young. I have faith in humanity's penchant to economize at the expense of society's fringes, and to somehow shoe-horn in "Science" for justification.
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    CoRE: Long Covid, Lyme and related conditions clinic at Mt Sinai hospital

    I would like to participate in that Mount Sinai effort. I thought I reached out to them, but never got a reply.
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    Multi-ancestry GWAS of [LC] identifies immune-related loci and etiological links to [CFS], fibromyalgia and depression, 2024, Chaudhary et al

    I can appreciate the good that can come from GWAS research. Validation leaps to the front. Possible therapeutics as well. I worry, I think, even more about the potential for harm. What if we find people that get fibro or ME/CFS or LC or late stage Lyme etc, all share common gene traits that...
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    Miranda Hart - British comedian

    A Lyme diagnosis can be perceived as toxic. I wonder which diagnosis carries more stigma: ME/CFS or Lyme. I suppose to a certain degree it depends on geography. Not sure it matters as much as it should, unless the objective is to compare levels of ineptitude. If the goal is to find out if...
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    Miranda Hart - British comedian

    Sheesh. Mischaracterizing the nature of a disease is seldom a good thing. Now that I think on it, it's probably always the opposite of a good thing. The Press needs to start showing some spine and walk away from the spoon fed boiler plate. In about 80 percent of the time. The rest of the time...
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    ME and PEM recovery via Cyclophosphamide (personal story)

    Invoking science standards to admonish a poster while using the Internet (when historically the Internet was considered by many as such a low bar) strikes me as ironic. Full stop. The observation was purely whimsical. That being said, I have been a supporter of researching on the Web, and...
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    ME and PEM recovery via Cyclophosphamide (personal story)

    Ah. Sorry. I must be dating myself. There was a time (not too long ago it seems to me) that using the Internet to uncover scientific facts or truth was considered a fool's errand, riddled with risk of misinformation, and anything but scientific. So. Ironic? Or not.
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    ME and PEM recovery via Cyclophosphamide (personal story)

    The irony that this is indeed supposedly a science forum accessed via the internet notwithstanding. :)
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    Maeve Boothby O'Neill - articles about her life, death and inquest

    Wild speculation? Don't wish to unpack all that, but why would it? Do you imagine we'd be able to distinguish it or even infer its persistence or lack of, no less prove it? All I am suggesting is that just because we fall short of certitude, doesn't mean we should rule possibilities out.
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    Maeve Boothby O'Neill - articles about her life, death and inquest

    It would no longer qualify as acute.. I'm not clear that this is accurate. I'm sorry, I have trouble with this. Could you clarify? Im not trying to be quarrelsome. It's simply that your position seems to dismiss any possibility that a newly discovered process, or stealth pathogen, or unknown...
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    Maeve Boothby O'Neill - articles about her life, death and inquest

    I'm not sure we can confidently declare this. It may be that they are related. We don't know. I thought the idea was to not be over-speculative and over-reaching.
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    Maeve Boothby O'Neill - articles about her life, death and inquest

    As chronic fatigue syndrome demonstrated?
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    Maeve Boothby O'Neill - articles about her life, death and inquest

    This may prove correct. It may also play out that it is precisely a neurological disease (or cluster of diseases that present similarly). Diagnostics aside, it sure has the feel of the latter. Characterizing ME/CFS as progressive is another matter. It seems to be up to a point, at least...
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    Hypothesis Microbes in mind - New Scientist article

    Diagnostics for brain infections are woefully bad, startling so. When I think of uncontested chronic brain infections, truly chronic, I think of the likes of neurospyphilis, and I believe tests even for that remain indirect. If you want direct testing for many of these neuro-infections...
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    How to understand it: Brain fog 2024 McWhirter

    "subjective phenomena"?? Which brain fog symptoms would be excluded from "symptoms"? And why is she acting like the use of brain fog is new, and is primarily a patient thing? In my experience I see doctors using it more, far more than I. I think it's dated and uninformed and demeaning - and...
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    Biomarkers for ME/CFS - discussion thread on the next steps for testing biomarkers, and why we need them

    Nevertheless, I suspect this may be what happens, only I doubt it's likely to be a single test, not in the near term at least. It is more likely to be a combination of tests, an algorithm e.g. low vasopressin, low NK cell function, low VEGF etc). Say three out of four or five values. Why a...
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    Chronic Fatigue Syndrome in Pets

    In many regards, dogs are the canaries in the coal mine. If I recall correctly, the way Canada estimated the spread of Lyme was through tracking canine (wolves?) migration routes. We all project. I am convinced my rescue dog is labouring with tick-borne diseases. Unfortunately, any diagnostic...
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