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So it's a phase 1 trial with 98 participants in 2 groups. One group gets the drug, the other group gets nothing, so it's an open label trial. I'm curious why they wouldn't go straight to a double blind placebo controlled trial. Edit: I guess because they are using it to test feasiblity and...

From the protocol Study Overview Brief Summary One in ten people following a COVID-19 infection develop ongoing symptoms which can last for months and even years. These symptoms affect people in different ways and have been demonstrated to broadly impact physical, mental and cognitive health...

The article this is about is published by Nature: Apoptotic stress causes mtDNA release during senescence and drives the SASP Long list of authors starting with Stella Victorelli, and ending with, Stephen W. G. Tait & João F. Passos Abstract Senescent cells drive age-related tissue...

Some posts have been moved to: Evaluating the Efficacy of Remdesivir for Long COVID Following a Confirmed COVID-19 Infection. (ERASE-LC), 2023, Mark Faghy, University of Derby, UK

This sort of word salad mind games by people whose training and interest is in history, philosophy and sociology really pisses me off. I'm sick, Ms Greco, I'm not interested in your philosophising and academic career. She reminds me of Shorter, another one who pontificates on ME/CFS and other...

Effect of the subjective intensity of fatigue and interoception on perceptual regulation and performance during sustained physical activity Aaron Greenhouse-Tucknott , Jake B. Butterworth, James G. Wrightson, Neil A. Harrison, Jeanne Dekerle Abstract Background The subjective experience of...

The study was done on healthy adult males, but there is also a bit about fatiguing illness, I think, so I'll start a thread on it for discussion. Effect of the subjective intensity of fatigue and interoception on perceptual regulation and performance during ...activity, 2022...

No it's not members only.

I sympathise with your difficulty, and hope you can find a way forward. I hear what you say about feeling you have nothing to offer, but a lot of people are not looking for outward signs of success in their friends or partners. Things like kindness, a sense of humour, willingness to listen...

Monica Greco is the Head of the department of Sociology at Goldsmith's University, London. Here's what they say about her: Previous forum threads on her work: Monica Greco (draft for 2017 paper) Pragmatics of explanation : creative accountability and ‘medically unexplained symptoms’ Michael...

I never heard claims that the vaccine give complete protection from either infection or transmission, but that it reduces both, as well as reducing the severity of infection, hospitalisation and death.

That sounds bizarre, @BazzaBoyle, I'm sorry you, and presumably the other patients that doctor diagnoses, had to sit through a nonsense lecture. What a waste of your and your doctor's time and energy. If they are so short staffed, how can they justify long appointments filled with lectures.

And yet she runs a clinic for years that pushes BPS to it's limits and is well known for misdiagnosing ME/CFS as FII when patients don't recover. So what does she believe? I wonder whether it's partly down to the disconnect between the doctors in the clinic who do the initial diagnosis, and...

Ah, thanks for clarifying, my sarcasm detector failed!

That sounds very judgemental, @duncan. I suspect a lot of the so called overlap between so called borderline personality disorder and so called MUS has more to do with diagnostic incompetence and prejudice by clinicians rather than anything real for patients.

And it's worse than that, as the psychobehavioural model is itself contradictory, with boom and bust diagnosed for some, and too much rest/deconditioning/fear of activity for others, so whatever the patient is doing is allegedly the reason they are still sick.

I don't remember seeing Esther Crawley adding her name to any of these general BPS articles. She puts her name to specific research papers done by her colleagues at Bristol/Bath on therapies for ME/CFS, but she's also a community pediatrician and professor, so covers all childhood illness...

This post has been copied and some subsequent posts moved from Anomalies in the review process and interpretation of the evidence in the NICE guideline for (CFS & ME), 2023, White et al I don't remember seeing Esther Crawley adding her name to any of these general BPS articles. She puts her...

That's a fantastic letter, @Hutan. Do let us know if it has any effect.

Most authors are from Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Aarhus, Denmark With one from general practice and one pediatrics. Seems an odd study to do. I mean, statement of the bleedin' obvious or what? What else would someone with physical...