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COFFI is wrong, DecodeME really is groundbreaking. It's the first bite of the cake.

Maybe we need to sorts of photos you see in articles whose subject matter isn't easily illustrated--often in the case of people ripped off or harmed by pollution. A picture of someone and their family sitting down in a setting that represents them or their community--like their porch or a park...

Really saddened at how they covered it, by assuming that his recovery from ME/CFS was some sort of personal achievement as opposed to a stroke of luck or a treatment that worked. Stoner himself said nothing about how or why he recovered. We don't know why recovery from ME/CFS happens, but it's...

Have any of us processed the data using false discovery rate (FDR) correction instead of Bonferroni? It would be useful to see what genes pop up when we use a looser test of significance, especially as a method of hypothesis generation.

That's disappointing. I was hoping they'd help a good number of people while being a bright spot in research and advocacy. But they only lasted about 2 years.

I like the writing style of this paper. When I read through the whole thing, it struck me as very comprehensible considering the subject matter. Unfortunately, a lot of scientific papers are extremely dense and you can only understand them if you're an expert in that tiny field. But Ponting's...

I don't trust research based on obituaries because somebody once used them to claim gay people had far shorter life expectancies in order to push their homophobic narrative that it's unnatural and dangerous. There's huge potential for bias: Some people's obituaries won't mention ME/CFS...

I'm very thankful for all the hard work your team put into DecodeME. I've been following it for so long and finally the results are coming out. I can't wait to see what it is. I don't expect a negative result at all. Not with 20k people. I predict that the genes they find will primarily be...

My bad. I assumed that they would be funding it if they're promoting it in emails, but I haven't heard they're funding it.

Why do I just imagine a headline in the style of Metro when I read this Town in Brazil where people can't WALK: Psychologists explain why

I'm very disappointed the OMF is funding this. There's no plausible mechanism by which water with hydrogen dissolved in it could help, and the previous evidence they gatheres is so low quality as to be meaningless. Edit: I don't have any evidence they're funding it rather than just promoting it.

The abstract sounds like absolute gibberish.

That's my city. I'm not impressed.

Gee, I'm glad for the thread because the abstract made it seem promising enough to definitely warrant a larger trial, when it's in fact slightly better than the Rituximab data. It would still be good to do a larger trial, but keep expectations modest.

They don't have a treatment but a supportive doctor can mean educating someone about pacing, helping them get disability benefits or trying to find a medicine that takes the edge of certain symptoms. It's unfortunate that Long Covid and PAISs are stuck in the pre-science era in terms of...

This is very good. it's a drug targeted at the condition's pathology and not gene therapy.

I don't dislike the whole paragraph. It just needed a little rephrasing. It's true that women in our culture are somewhat more likely to be conscientious about their health. (It's probably not enough to explain a 2-3x difference in prevalence though.) But you're right, that point isn't essential...

Thank you to the authors for taking the time to write your thoughts in this paper. You have an interesting and novel hypothesis. As a non-expert, it seems as plausible as any other model of ME/CFS I've seen thus far. I don't think the wording on topics that could be confused with BPS is...

Same here, I started taking 2,000 IU of vitamin D a day, thinking it might help my energy, and it didn't.

https://www.phoronix.com/news/Several-Linux-DRM-Orphaned Several Linux DRM Drivers Orphaned Due To Developer Health One of the developers on the Linux Kernel has had to step back from maintaining a few drivers due to a "fatigue illness". While it's a small story, and the developer chose to...