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I love seeing a study that admits it found nothing. We need more of these! It will prevent researchers from turning over the same stone repeatedly.

Wow, never expected Claude Shannon to come up here.

I lost three years of my life because I had ME without knowing it, because doctors wouldn't diagnose it. I discovered ME by a Google search.

Let me transcribe. Michael Gordon: They're making her life impossibly difficult in hospital, but they won't give her community care either. The community virtual ward service is saying they won't give IV fluid support on the community. So we can't be in hospital, we can't be at home. So we're...

Now imagine how many papers are egregiously bad methodology are out there, but are challenged by nobody because their subject isn't one of enormous public interest.

It would be easier to list the trials we can trust over the trials we couldn't. There are studies that deliver certain results, and a long tail of studies that mean little, either because they're highly speculative, or methodologically flawed.

Interesting. Gene expression--the search for how cells choose which proteins to make and how much--has perplexed scientists for so long. Hopefully this will unveil something.

I'm surprised you have a negative opinion of this. I think it's great. People at one of the world's largest drug companies are outright saying LC is biological. It's part of a trend of post-infectious illness gaining acceptance within mainstream science and medicine. It makes me wonder if they...

Seems like a gray area gray area if you ask me.

The problem with that is...there's an obvious mechanism. "True" psychosomatic diseases, like what Chalder and Wessely support, don't have actual causes, it's just Anxiety ??? Profit! We accept that health issues can have physical or mental/emotional causes. But the modern psychosomatic school...

When I got a sleep study I slept about 3 hours out of the whole night. I think the main cause was that the wires prevented me from tossing turning naturally. I move around a lot, often waking up in a different position than the one I fell asleep in, or finding pillows on the floor.

This describes my experience perfectly, but unfortunately, she uses this as evidence ME is mental. A better model is that of oscillation of a dynamical system. When there's a delay between the input and output of a system, oscillation emerges. We see this in springs, where the the force...

Well, the argument that it's easier to get hired in a couple weeks to deliver pizzas for $15/hr makes it unlikely a rational person would fake illness. However, the doctor in that thread claimed pwME subconsciously made themselves sick. Which I don't think is a falsifiable statement. There's no...

Recently, I saw an S4ME discussion about a Reddit thread, and in the Reddit thread, a doctor accused people with ME of subconsciously making themselves sick for secondary gain. That inspired me to look up research on malingering. Disturbingly, most papers claim malingering is very common. For...

You need to be able to give useless studies zero weight in reviews, instead of a very small weight.

The next cohort is long Covid.

Definitely. I predict we'll discover their pathology is very similar, if we can unravel GWI before most of their cohort passes away and can't be studied anymore.

It's great that post-infectious illness is going mainstream to the extent a more general scientific body appointed a specialist in them as president, and published a call for more research into them.

I can't believe people with GWI have suffered for so long (30+years) with so little research. I know pwME have done the same, but I've only been ill 5 years and entered the ME world in 2021, when LC was well-known and the new NICE guidelines came out.

Might be a combination of media tending to cover the same stories in unison, research on the financial cost (nothing worries the rich/politicians like the economy), and finding a gene (which makes it more "real").