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It's a concern. The authors point to two issues that might be behind the lack of replication. 1. For technical reasons (that they will address in future studies), they weren't able to run a full replication and are likely to have missed true positives. 2. The cohorts were less than ideal, coming...

Link with Long Covid & MS - work underway I didn't include this in my blog because of my concerns about the accuracy of gene identification I mention above, but I still find it very interesting. Using a hypothesis-free combinatorial analytics approach based on the PrecisionLife platform, we...

Thanks, it's a very interesting idea, but you may have overestimated by PowerPoint skills. What the paper doesn't show is the link between subgroups and genes. Or even clear description of subgroups e.g. (hypothetically) infectious onset in teens, POTS, more severe - because there is limited...

I've now published a blog, thread https://www.s4me.info/threads/blog-new-study-links-14-genes-to-me-cfs.29511/#post-437195 Thanks for the feedback on the graphics I posted. It was clear I need to make some changes to keep everything clear, I'm afraid I ran out of energy. I might add them later.

New Study Links 14 Genes to ME/CFS A study has analysed existing genetic data in a new way to link 14 genes to ME/CFS and identify many patient subgroups. If the new approach pans out, it could transform ME research and turbocharge the development of treatments. Paper: Genetic Risk Factors for...

Hi, I'm looking for some help with my blog. Assuming everyone on this thread is aware that in this study Precision Life uses combinations of SNP's (between three and five), which it calls disease signatures. Then it searches for all the patients with the same disease signature (actually, it...

PrecisionLife would argue that this could be due to subgroups. The largest subgroup they identify covers 31% of patients. Let's say this is an autoimmune subgroup: if only 30% of those treated with rituximab had an autoimmune disease (and assuming rituximab was the right autoimmune drug), it...

I'm aiming to get a blog out later in the week and I'm talking to 1 of the researchers this morning. It's onw of the most complex papers I've ever read, so it might take me a while. Briefly, this approach, by a techbio company, uses a novel analytical method on existing genetic data (from the...

This is now sold out - will videos of the sessions be made available in due course?

Sorry to hear that, Andy - hope you make a good recovery from Covid Best - one of the disappointed hordes.

This rather excited opinion piece by psychosocial enthusiasts is founded on getting the maths wrong. Their great "insight" is that the association between MS and EBV is generally weak, and only strong for the 36 cases of MS who were EBV negative when they join the military and 35 subsequently...

It's worth remembering that this is Covid, where severe infection means hospitalised, ICU and sometimes death. Even 'mild' covid is often pretty nasty and might well compare with the illnesses included in the Dubbo study (glandular fever, Ross River Virus and Q fever) I think it would be worth...

Worth bearing in mind that the original analysis (backed up by this new one) found that the only significant predictor of CFS at 6 months was the severity of the initial infection and not psychological factors. I think all the data in the original study came from analysing SPHERE data...

We wouldn’t have either budget or ethical approval for this. But other researchers could apply to recruit from Decode ME participants who have consented to be approached about joining further research studies. research is within also have the genetic data on these participants. That’s one of...

the different figures are because they needed to use different statistical approaches for different sets of data. The hazard ratios for illness severity and mood disturbance are hazard ratios of "recovery" (I know, it's odd) and the data is the number of days for recovery for each patient. They...

Commentary: a (fruitless) search for biopsychosocial gold? In a nutshell: this appears to be an unsuccessful attempt to find biopsychosocial gold by looking to see if neuropeptide Y (which has links to anxiety and stress) is linked to developing CFS after an infection. There is no link, and...

I agree. My understanding is that the reason for most research studies requiring the 50% reduction in function is to give greater certainty of diagnosis. As you say, it might be valuable to study milder cases that won't have the confounding factors associated with long-term chronic illness...

I think this is important work. There are many small studies out there - what we need is to see the big picture. Key findings in test-retest: 21w (95%CI −38 to −4, tau = 9.8) pooled mean decrease in work rate at the anaerobic threshold (four studies). 8.5W (95% CI −15.38 to –1.72) pooled mean...

Thanks to everyone who has replied here or messaged me privately. The feedback and suggestions have been very helpful in deciding what to do next.

On the one hand, this makes sense. There are specialist journals for many illnesses. On the other hand, I wasn't aware there was a problem getting good quality ME papers published. There is also Fatigue: Biomedicine, Health and Behaviour, which is ME-friendly and has people like Lenny Jason and...