Search results

And there’s nothing like a big pot of money – in this case about £25 million – to get the attention of researchers from outside the field.

They’ve been quite a few studies since then and it does seem to be reasonably good for 25% equals housebound. Eg Pendergast

Why is this is a thing worthy of mentioning in the abstract? It is why almost all people consult a medic, regardless of their illness. I wish medics and researchers shared patients' motivation to search for physical mechanisms.

Not as far as I know. Taking any medication won't affect your DNA. Possibly if you were on strong chemotherapy that causes severe fatigue, but I can't remember if that's in the screening questionaire.

:rofl: Possibly the best quote about research that I have ever read.

I hadn't seen this posted anywhere else. Listening to it now. Focuses on the immune system. Yale's Akiko Iwasaki is always good on Long Covid even if the Guardian and the interviewer, Ian Sample, are not...

@Snow Leopard Nice analysis. If I've understood you right, you are saying the authors have shown decent antibody binding of GlialCAM (which could explain MS) but only weak binding against EBV protein EBNA1. And that this could just be because the glialCAM ab happens to bind EBNA weakly - not...

I can't access the paper. Here's the Work and Social Adjustment Scale https://www.networks.nhs.uk/nhs-networks/regional-mental-health-commissioning-networks-portal/documents/wsas.pdf "People worried more when their ME/CFS caused worse problems with being able to work, socialise, manage a home...

DecodeME has tweeted about the relevance of this to ME/CFS. And the MRC retweeted DecodeME...

A new paper in Nature says: Here we demonstrate high-affinity molecular mimicry between the EBV transcription factor EBNA1 and the CNS protein GlialCAM, and provide structural and in-vivo functional evidence for its relevance... Our results provide a mechanistic link for the association between...

Comments For me, the most striking thing about this well-done study is that it finds two biologically coherent groups of symptoms among those with long covid: one a post-infectious ME/CFS and POTS-like cluster, e.g fatigue, brain fog, memory issues and palpitations. the other a chest-based...

This excellent Scientific American article covers the paywalled article. Some comments, mostly based on the SA piece. Study method Researchers had long suspected a link between MS and EBV but it's hard to study the connection when 9 in ten adults are already infected with the virus. This came...

New member-only thread DecodeME - which studies should we be able to compare results with?

I asked Chris Ponting who said he thought were referring to: PHOSP-COVID (hospitalised individuals), REACT-LONG COVID (whole genome sequencing for a couple of thousand people) or Sano Genetics (a few thousand, whole genome sequencing).

well, the data from the (edit) GWAS should prove a useful test for the vast number of competing hypotheses that are produced to explain ME/CFS. However, not finding a genetic signal would not be definitive, especially for a single GWAS of 25,000. It's not a small study, but hopefully, over time...

Of the 892k who first caught covid at least 12 weeks ago, 178k report that the symptoms limit their activities of daily life a lot (for comparison with ME/CFS).

Poll closed, 90% in favour of the Getty Images collection put together by PwME Thank you to everyone who voted in the poll, which is now closed. 90% of you agreed that the photos are a worthwhile improvement on the ones currently used in the media. This means we can now pass on the collection...

Thank you to everyone who voted in the poll, which is now closed. 90% of you agreed that the photos are a worthwhile improvement on the ones currently used in the media. This means we can now pass on the collection of Getty Images photos to charities explained there were selected and approved by...

thanks. I think DecodeME got £3.2 million funding. I would need to check but actually, I think DecodeME might be doing whole genome sequencing and I think that costs about $1000 per person, so £10 million for a study of 10,000 people. I'm not sure on the numbers. But I think the timescale is...

Whoops, this somehow grew into a blog. Apologies. Like the DecodeME study, this exome study of UK Biobank data compares DNA between people with a condition (in this case ME/CFS) and healthy controls. Significant differences point to a cause of the condition. But the two studies go about this...