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Moderator note. This post has been copied and following posts moved from this thread: Possibility of ME or PVFS after Covid-19 Big thanks to @Andy for posting this. I posted similar on Twitter and got very lucky It's amazing and, hopefully, this will lead to serious action by the WHO.

I am planning to write a research blog about the link between Long Covid and ME/CFS, and am hoping the smart people here will help me out. I must have missed at least 1000 posts since I last kept up with this thread. There's no way I can read all of them so if I outline what I think I know...

Some notes from me (relevant sections with key bits highlighted) I was struck by how much lung/breathing/cardiac issues were common - so very different from ME/CFS in that respect (I suspect co-morbidities were different too). Also many similarities, and I have focused on things that look...

Lots of great analysis on this thread (no surprise there). One point that I didn't see mentioned was that the comparison here is with baseline i.e. there is no control group (such as a waiting list control group). People may modestly improve over time in these situations regardless of bias...

Sorry, no grounds for talking therapeutic approaches without a replication. Corrected now

I do like the idea of using sub-maximal exercise and measuring pre/post differences in brain function during a cognitive challenge. The sample size was big by the standards of fMRI studies (38 ME/CFS; 80 GWI, 31 Healthy) but still small. I'm not sure that the sub-maximal test, based on 25...

Thank you for what you were doing to support this project, it’s an inspiration to the rest of us.

Yes, this is the same basic TSPO-PET MRI method as the Nakatomi neuroinflammation study indicating activation of microglia (see my blog). Though it's not clear if they use the same radiotracer to light up the glial cells (radiotracers have since got better, apparently). However, the recent...

The Netherlands is set to make a huge investment in biomedical research A patient-led petition asked the Dutch parliament to tackle ME properly. It instructed the Government to take action, which eventually led to the Dutch health research agency recommending a €25m biomedical research...

Thanks! Full credit to the first author Joshua Dibble, Chris Ponting's PhD student, who is funded by Action for ME and Scotland's Chief Scientist Office, and to @Chris Ponting himself. Yes- perhaps it should say, "and these costs are declining". The concluding section might be worth sharing...

Responding to tag. I am afraid I am not able to look at this at the moment. However, there is a review paper in press that looks at these issues and might be available quite soon.

Suggestion: @Andy Devereux-Cooke is an investigator for DecodeME, the world's largest ME study. (Oh, and thanks for including me :))

This looks to me like a very elegant approach. On the one hand, you have McEvedy and Beard who simply read the medical notes from the 1955 epidemic - choosing not to contact either the patients or their treating doctors - and drew a conclusion that fitted their beliefs. That seems to be a...

“Feel the love – and the heat” :-)

Jazzed up version of my blog (thanks for the original link @Andy) UK spends £3 million on the world’s biggest ME/CFS study June 23, 2020 Simon McGrath £3.2m of government money will fund DecodeME, the world’s biggest ME/CFS study, which aims to recruit 20,000 patients. It will analyse DNA...

I've been volunteering on the team and strongly endorse this - Sonya has worked incredibly hard and very skilfully. And I don’t think the study would’ve happened without her either. Thanks, Sean :) Love that "arm-in-arm with people with ME and charities" line.

I tend not to quote stats in my blogs, but I only blog about results that are statistically significant. Here are the stats: HLA-C*07:04 (OR 2.1 [95% CI 1.4–3.1]) HLA-DQB1*03:03 (OR 1.5 [95% CI 1.1–2.0]) OR is odds ratio (chance of having it as a patient relative to controls). The confidence...

Would really appreciate any shares: https://twitter.com/i/web/status/1253646885518225408 https://www.facebook.com/topmecfsresearch/posts/947087762412841

Good question. What I meant was that these alleles did not of themselves cause ME/CFS, not in the way that faulty genes cause cystic fibrosis, for instance. Instead, they contribute to getting ME/CFS so what the study really measures is an increased risk of getting the illness (about 50%-100%...

The best evidence yet that immune system problems can cause ME/CFS? Human leucocytes Antigen (HLA) proteins play an essential role in helping the immune system to recognise pathogens. This new research is easily the best study yet of HLA alleles (gene variants) in ME/CFS. It finds links...