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Thanks to all those continuing to toil on this thread. Took me awhile to realise how little I understood of the detail of this method and how out of my depth I was. Though I’m assuming that, regardless of my ignorance of the black box, if the results replicate and hold up using sick controls...

According to figure 1 (A, B) The nano needle has two thin gold electrode layers sandwiched between three (Insulating?) oxide layers, presumably current flows between those two electrode layers via the fluid, but influenced by the close proximity of the cells, or even cell contact. According...

That is unknown, though “just a reaction to being circumstances” seems to be underplaying the problem. Certainly some cases seem to be caused by immune problems, and that’s an active area of investigation. But non biomedical problems can cause very serious depression.

They have a plan Just about every other "potential biomarker" has faded away . What is encouraging about this one is both the dramatic difference between patients and controls, and the fact that they have a clear plan to develop it. First, they aim to test the performance of the assay on...

Sorry come I had assumed you had seen that’s because of your question about the geometry. As someone without any experience of PBMC is suspended in plasma, I had assumed that there might be some local forces attracting the sounds to be electrode. But also, I had assumed that some of the cells...

"What" is a lot easier to answer than "why". They produced "simplified blood" of each patient made up of PBMCs resuspended in plasma, 200 cells per microlitre. A sample of this was added to the Nanoneedle chip and they then measured in impedance. Impedance is defined as the ratio of applied...

This is the key issue, particularly given the frequent claim that this shows ME/CFS is not "all in the mind" (I really dislike that phrase because it denigrates mental health problems). Depression probably has a stronger immune signal than ME/CFS. Michael VanElzakker has pointed out that you...

In the discussion, the authors say "According to our experimental results, ME/CFS blood cells display a unique characteristic in the impedance pattern…" Yes, as they go on to say, it is significantly different from healthy controls. But no one has a problem distinguishing ME patients from...

Have had a quick read through The paper and thought I'd place here before I went to bed. They do claim that the finding is unique to ME/CFS. So those comparisons with sick controls are essential. As I think everyone has pointed out, bigger samples are also needed. Though the Stanford piece...

Both groups use the same method, the Seahorse analyser. as Lisa says, the findings are consistent because the most obvious exclamation for the load oxygen consumption in ME/CFS plasma is increased mitochondrial activity, the same as Fluge found.

Blog preview Something in the blood It is remarkable that four independent groups have now found that a factor in the blood can affect cell metabolism/mitochondria in ME/CFS and transfer the effect to healthy cells. Here is a summary of the provisional findings. Fluge & Mella The first to...

"Something in the blood" Moderator note: Simon's summary of what we know so far about the "something in our blood" has been relocated to this thread, https://www.s4me.info/threads/blog-summary-so-far-of-something-in-the-blood-by-simon-mcgrath.9168/

EDIT: SUMMARY OF LATEST VERSION OF BLOG POSTED INSTEAD Moderator's note: This post and relevant replies have been copied from this point, https://www.s4me.info/threads/nih-accelerating-research-on-me-cfs-meeting-4th-and-5th-april-2019.7745/page-14#post-161538, in the Accelerating Research on...

I have been in touch with Dr Kathy Rowe, the sole author of the study, who was really helpful in providing additional information. Several points she mentioned are worth sharing (with permission): 1. To count as recovered, patients both had to say there were recovered and to specify how long...

Unfortunately, my migraines are getting ever worse and I probably won't be able to return to this thread after this post. Yes, the distinction between remission and recovery is very important. In this case, though, I think most of the results will cover recovery. If you look at the group with...

The Brown, Bell and Jason paper from 2012 is important in relation to the new study as it aims to see if patients who said they were recovered really were or not. They did this by checking if symptoms and function scores were consistent with recovery, and found "that over time many individuals...

Could you tell me where I could find a clip where he says this, please? Thanks

Commentary [Relatively good] long term outcomes for young people with ME/CFS Katherine S Rowe, 2019 apologies that I haven't taken part in this thread - awful migrainesmeans screens are deadly (I read the paper in print, dictated wtih Dragon and a friend cleaned it up for me). This is a...

Brief commentary An interesting approach to studying "neuroinflammation“ yields only one robust finding. Jarred Younger is looking for evidence that would support hypothesis that ME/CFS is driven by low-grade immune activation in the brain. It's an interesting approach using widely-available...