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I don't want to become the defender or spokesperson for this technique, but it does proceed based on that premise: we dont know what's wrong, so take an unbiased approach to see what drug makes things look like healthy cells again. Walder used it in diabetes, he told me. Here's a couple of his...

This could also be a good thread to share a post I found in a facebook group for the in-ear wearable device that measures bloodflow to the head. I'm sharing this post because I think it moves the goalposts in a really useful way; if everything else is just a proxy for getting blood to the head...

I've recently been focussing more on the orthostatic intolerance side of my symptoms; i regret not looking into this more before because there's some simple things that seem to help. I have bought compression garments, which I'd used before and kind of given up on but these new ones seem to...

@Creekside I suppose if the book made all the claims you're guessing it makes it would be a bad book! I asked chatGPT though and it said guessing at what's inside a book is not in the top few ways to find out what's in a book. ;)

I just joined their facebook group where they are sharing some data from some staff members with POTS. (Seems like they hire people with POTS mostly, must be a weird office!) I also watched this video there's an interesting moment where the researcher shows how drinking coffee causes her...

There's the consumer version which prioritises battery life(right in pic) and the test-bed one that runs continuously and produced the charts above (left in the pictire below. It is bigger) They're also trying to program the consumer one so it starts measuring more intensively when a person...

Here's a paper for you @jnmaciuch! These guys find d-malate inhibits metabolism (in mice). This is one of those chirality things ... What's the mix of L and D malate in natural foods vs in supplements? . 2024 Feb;25(2):524-543. doi: 10.1038/s44319-023-00028-y. Epub 2024 Jan 22. Microbiota...

I'd like to make two little points that leave me keen to do structured testing on folk remedies. 1. The idea that "if it worked, we'd know by now" is probably not true for a range of useful treatments. Patients are so variable, approaches to testing common products are so variable (e.g. i...

One hour update: I felt pretty cheerful over the last hour but I also realise I misread the post and took an amount measured in teaspoons (approx 7 or 8 grams) not 2 tablespoons (30-40g?). Also I wonder if the absorption taken with yoghurt might be slower than with water. Overall in...

well, why not? Doesn't taste too bad. I'll let you know how i feel!

It's expensive; not totally out of reach if it actually delivers better ability to manage symptoms. For me i'd need to buy an iPhone to make it work so that's extra expense too! However it's not available in Australia so it's all a bit academic.

I just watched this video and found it quite intriguing. The following four screenshots show examples of the device measuring drops in blood flow. It measures a proxy for blood flow to the brain but nevertheless looks useful @SNT Gatchaman you called for this to be done and they have...

One thing Levin won't stop talking about is the idea that electric charges predate neurons by a long way and are a more ancient way of coordinating and arranging things. They're present in algae, for example. I'm with him up to that point but he proceeds to talk about electricity as a form of...

This is why the book review starts on the defensive ! People are strongly repelled by the idea of electricity in biology. Among the ways they do it: https://en.wikipedia.org/wiki/Gap_junction Among the cool things explained by electric charge is how embryos work out left from right, placing...

Here's a graphic that shows Hwang's new wasf3-centric view of the universe! Figure 1. A model of how WASF3 may play a central role in regulating metabolism and immunity in response to ER stress and other signals. Upon ER stress, the level of WASF3 protein may rise at the contact sites...

Got my hands on the paper itself. My read is he is not phoning in a cheap review for citations; quite the opposite. He seems consumed by the idea WASF3 could explain everything. Everything! A relevant excerpt: Potential clues that WASF3 may be involved in the immune system come from early...

I'm interested in science's blind-spots and forgotten ideas. Things we knew but which were forgotten; thing we know but have become unfashionable to mention. So when I recently read about Tufts Professor Michael Levin and his amazing research on how electrical charge helps determines organism...

What great news. This is such a weird illness! Enough spontaneous worsening that you can never get too comfortable, and enough spontaneous improving that you can never give up hope !! I'm hopeful he could gain more function. If I know anything about mecfs it won't be a straightline trajectory...

Perhaps this could be part of the etiology of mecfs, a possible mechanism by which the "hit and run" theory could work: The virus affects the endoplasmic reticulum in certain cells, such that the unfolded protein response is turned on. Even if the virus is gone or mostly gone some of its...

Orchestration of SARS-CoV-2 Nsp4 and host-cell ESCRT proteins induces morphological changes of the endoplasmic reticulum Allison Kifer 1 , Franciso Pina 1 , Nicholas Codallos 1 , Anita Hermann 1 , Lauren Ziegler 1 , Maho Niwa 1 Affiliations Affiliation 1 University of California, San...