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POssible linkages here from adrenergic theories of me/cfs / cerebral blood flow theories of mecfs to why sleep is non-restorative in me/cfs, but you'd need a lot more work to establish them as any sort of fact. Still, could be worth someone applying for funding to look at cerebral blood flow...

I'm happy to answer this but I don't want anyone to think I'm recommending this for them. I've had mild me/cfs for 22 years now and I know my body and this is what works for me: Walking has usually been the worst idea for me. I can walk a bit - I'm mild. But there's a hard limit and I can't...

I find this very interesting because of an effect I've noticed when i'm on a diet: high risk but slow-building benefit. if i reduce my food intake, I risk acute energy shortage if I push too hard, and that can cause PEM. However, if I succesfully avoid that acute problem, the calorie...

I recommend against exercise. But I am also open to this being a situation where the poison is also part of the treatment. Consider electrolytes in cholera. Until they figured out the perfect osmotic ratio for electrolytes in oral rehydration solution, giving electrolytes killed the patient...

This feels like a gigantic pivot from Scheibenbogen away from autoantibodies. Maybe overdue!? But the hypothesis is far too strong given the state of the data. Based on our current knowledge on the known causes of muscle damage related to exercise and malperfusion, diminished function of ion...

That's unbalanced enough that despite the label I'm wondering if they've actually remembered to log transform on the x-axis. (A protein can rise by more than 100% but not fall by more than 100%)?!

It may have been Naviaux 2017, Sphingolipid was among the strongest findings there : This idea also brings Naviaux's thinking to mind, with his theories about failure to wrap up the cell danger response. Seems he has coined the term "salugenesis" to describe returning to health. Salugenesis...

A parallel expression is "climate skeptic", and they're usually skeptical of there being a problem at all. So my vote is for a name change. I suggest ME/CFS Science Reviews.

I have never stopped thinking about this study and I keep an eye on any new research on UPR. I recently found this pre-print and contacted the senior author to see if he had any thoughts on me/cfs. Hwang's WASF3 paper found a disregulated pattern in the UPR proteins that you'd usually expect to...

I agree with this approach. Worrying about absolute p values isn't as important as ranking things and seeing if those things show up near the top in other studies. That's when there's actual signal. Another bit of info for anyone scrolling the mega list of correlates with severity, the acronym...

Couple of points @forestglip 1. I'm loving the embedded google sheets, that works really well for me. 2. I'm very impressed by your interrogation of the data and your commitment to extracting the true value from it. I notice you're not afraid to put in the effort. ;) 3. I believe Benjamini...

This is an unusual but deeply-researched paper, by leading biologists out of MIT in the US. Their work is beautifully explained by @SNT_gatchaman . If I understand it right they're proposing a whole new hypothesis for why oxidative stress can impair cellular function: simply by slowing the...

this is by Kathryn Melamed, now of UT Austin. She was publishing on me/cfs before covid, with systrom: https://www.s4me.info/threads/unexplained-exertional-intolerance-associated-with-impaired-systemic-oxygen-extraction-2019-by-melamed-systrom-et-al.11176/ This paper has impressive scale. It...

Me a few years ago, naive: Novel biomarkers, YES! Me now, jaded: novel biomarkers, UGH. Nobody ever follows up some random lab's weird expensive technique.

IN the long run I don't seem to be able to improve my exercise load, but in the short run, sometimes. I've at times increased how far I can walk, increased how much I can lift, increased how far I ride, etc. Later I crash and it all goes backwards. And its all gone backwards on net over the last...

Moved post I was looking for a good thread to put in some interesting recent progress I've made on IBS, and this one will have to do. I had been taking a certain probiotic on and off for the last few years but I think i've finally separated signal from noise and realised it si very effective...

An interesting matrix to explore with a survey might be I have POTS symptoms, am alcohol intolerant I have POTS symptoms, am NOT alcohol intolerant I have NO POTS symptoms, am alcohol intolerant I have NO POTS symptoms, am NOT alcohol intolerant

I would like to reiterate my original post: DOMS and PEM are different. DOMS is adaptive. PEM is pathological. DOMS is local. PEM is systemic. One is a system working. The other is a system failing. That doesn't mean they can't be using similar pathways. In one the pathway may be working, in...

Near the beginning of my me/cfs adventure, I was in what was essentially remission. I'd been sick really acutely for about 4 months, then suddenly and spontaneouly "recovered." I could exercise. Or I could go drinking. But the combination was a cause of PEM. I learned to separate alcohol and...

There are a couple of athletic phenomena that could share some similarities with ME/CFS. Over trainign syndrome is one: My understanding of this term is it refers to a long period of feeling weak, perhaps months or weeks of reduced performance that is alleviated only by rest. A sort of...