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Ok, I wasn't positive if the OR is always based on the minor allele frequency, but that's probably right. I got the same. Edit: So I think that means the gene expression database is saying that if ME/CFS has the T allele less often, expression of CCK would be higher in cultured fibroblasts and...

Good thought, I'll send a quick email to him.

So the only significant finding in terms of genetic mutations was a SNP which affects the expression of CCK (aka cholecystokinin). The database they used seems to say that this SNP decreases expression of CCK in cultured fibroblasts but increases expression in colon cells. I couldn't figure out...

Functional Connectivity Changes in Long-Covid Patients with and without Cognitive Impairment Manuel Leitner, Daniela Pinter, Stefan Ropele, Marisa Koini [Line breaks added] Abstract Long-Covid is associated with cognitive deficits in memory, attention, or executive function. However, the...

Beyond fatigue: an intersectional analysis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and social identities Zoe Sirotiak, Emily B. K. Thomas [Line breaks added] Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, chronic condition...

I'm not sure that it's been studied much. I was mostly just extrapolating based the potential link in long COVID. Though even if severity isn't associated with ME/CFS, it seems likely that frequency of getting infections would be associated. If someone never gets infections, they can't get a...

Epigenetics/DNA methylation They continued by testing methylation differences between ME/CFS and controls. DNA methylation is the biological process where methyl group molecules are attached to the DNA at specific locations, which affects the expression of genes, but the DNA itself doesn't...

I'm interested in this study because the following review found that, out of the six GWAS/TGAS that had been performed prior to 2020, only this one performed all the recommended quality control checks for a GWAS: Review of the Quality Control Checks Performed by Current Genome-Wide and...

Final paper published December 2018: Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Santiago Herrera, Wilfred C. de Vega, David Ashbrook, Suzanne D. Vernon, Patrick O. McGowan [Line breaks added] Abstract Myalgic Encephalomyelitis/Chronic...

Summary of the quality control checks they recommend that GWAS studies perform: And here are the summarized results of their quality control analysis of the 6 GWAS or TGAS that had been done at the time: Only Herrera et al performed all these recommended quality control checks. They give...

Am I misunderstanding what "Cor. #Treatments" and "Cor. Symptoms" represent? How can a correlation of .00001 give you a p-value of .01776? All the "most perturbed plasma proteins" have tiny correlations with number of treatments or symptoms, yet significant p-values with only 31 participants...

I agree. I feel like with expression, metabolite, brain imaging findings etc, ~90% of the findings might easily end up being products of lifestyle: low physical activity, diet, medication, etc. We've got a handful of the really good stuff, the genetic causal studies, with another really big one...

Things I want to keep an eye on, after reading and discussing the paper with an AI to better understand. (AI quotes slightly edited for clarity and links to GeneCards added): CSMD3 and PTPRD had many significant variants, and included some of the lowest p-values and largest effect sizes of the...

Vitamin D blood levels and vitamin D receptor polymorphisms contribute to post-acute sequelae of severe acute respiratory syndrome coronavirus 2 severity in the pediatric patients Pei-Chi Chen, Yu-Lung Hsu, Yen-Hsi Chen, Chih-Yu Lin, Miao-Hsi Hsieh, Hui-Ju Tsai, Wen-Shuo Kuo, Hui-Fang Kao...

Commentary: Efficacy and safety of Xiaoyao San in the treatment of chronic fatigue syndrome: a systematic review and meta-analysis Runhua Zhang, Hongxia Hu We read with great interest the recent systematic review and meta-analysis evaluating the efficacy and safety of XYS for the treatment of...

Open Medicine Foundation: 'Steroid Dynamics in ME/CFS: New Publication' The Heart of the Matter OMF’s research centers in Uppsala and Melbourne published a study of steroid hormones—molecules that control a lot of important systems in the body—using an advanced technique called...

Steroid dynamics in myalgic encephalomyelitis / chronic fatigue syndrome: a case-control study using ultra performance supercritical fluid chromatography tandem mass spectrometry Natalie Thomas, S. J. Kumari A. Ubhayasekera, Christopher W. Armstrong, Katherine Huang, Jonas Bergquist [Line...

I see that a new version was submitted on July 11 and posted on July 15. They did a big overhaul of the references. I checked a handful and they seem to be real papers now. Nothing about the text is changed except they updated/added citation numbers and removed the bit that said they used AI...

That result doesn't feel very strong. Higher CD8 in only one of five six symptom-based subgroups, and not even in both sexes. Edit:

CXCR5 on Wikipedia: