Achieving symptom relief in patients with ME by targeting the neuro-immune interface and inducing disease tolerance (2020) Rodriguez et al

[Sid]

The idea that something could be accomplished by stimulating the trigeminal nerve goes back to 1990s and Goldstein. No idea why they’re using buzzwords and saying incorrect things like

critical neuro-immune interface and mediator of the inflammatory reflex which regulate systemic inflammation

hypothesis that ME is a condition caused by a failure of inducing disease tolerance upon infection and persistent immune activation

There is no systemic inflammation in ME. No immune abnormalities reported in ME have ever withstood replication attempts. Steroids and NSAIDs do not work.

 

[forestglip]

Am I misunderstanding what "Cor. #Treatments" and "Cor. Symptoms" represent? How can a correlation of .00001 give you a p-value of .01776? All the "most perturbed plasma proteins" have tiny correlations with number of treatments or symptoms, yet significant p-values with only 31 participants.

Fig 2E:

"(E) Mixed-effects modeling shows the most perturbed plasma proteins and immune cells that change in response to therapy and in relation to symptom scores."