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A goal in experiments is to control for as many confounders as possible to increase the chance that any positive results are actually related to the outcome of interest. My concern with just taking a bunch of people with ME/CFS and a bunch of controls and doing a GWAS is that you might get...

I was probably being too hard on them. It is definitely necessary to verify these are SARS-CoV-2 peptides. And maybe they do plan on comparing to recovered controls. This is only a correspondence, not a full paper, so maybe they just wanted to get their initial results out quickly in case others...

Well currently journal editors already determine that. Maybe the difference could be that the person who reported something to a journal which eventually led to a correction or retraction gets this linked to their name. Although probably a good way to be ostracized by some in scientific...

True, good as a control to be sure they're testing what they want to be testing. But would it have been so hard/expensive to find 20 more samples from the 5 years since?

Why use control samples from before COVID? Of course they won't have SARS-CoV-2 proteins. We're interested in whether people who have had COVID but didn't get long COVID have those proteins.

Possible long COVID biomarker: identification of SARC-CoV-2 related protein(s) in Serum Extracellular Vesicles Asghar Abbasi, Ritin Sharma, Nathaniel Hansen, Patrick Pirrotte & William W. Stringer [Snippets from correspondence with no abstract, bolding added] Web | PDF | Infection | Open...

Associations between lung and endothelial function in long COVID: Two years after acute infection Lêda Leonôr Mendonça Carvalho, Cássia da Luz Goulart, Gabriele Da Dalto Pierazzo, Ester Laura Cordeiro-Costa, Audrey Borghi-Silva, Adriana Sanches Garcia-Araújo Highlights • This is the first...

I'm imagining if a treatment was widely released and tried with a portion of people recovering and a portion not. There's a good chance there'd be different DNA signals in the two groups that become much clearer when they are looked at separately. And it'd be much cheaper to hold on to existing...

I sent an email to the coroner.

That the finding probably isn't consistent in all people with SSRD (maybe different underlying reasons for getting the diagnosis in the other cohort), if it's a meaningful finding at all. Edit: Or it's a very tiny effect that the smaller sample size couldn't detect.

Oh yeah, opposite direction too for the main SNP (last row):

Or maybe there is a lot of heterogeneity, but they identified a gene responsible for only a subgroup. With such a large sample size (22k), that might have been enough to get significance for a gene related to only a portion of these people's diagnosis.

But they got a genome wide significant hit. Maybe it's because the gene makes people seek out FND practitioners or participate in studies or some other non-interesting reason. Or maybe the people who get FND/SSRD diagnoses do have some biological causal factor in common, even with the diverse...

What specifically is the concern? You'd agree that the FND group is likely sicker on average than the healthy group, right? If a gene was significantly associated with being in the unhealthy group, then there's a good chance it's causal for being in that group.

GeneCards: CYP7B1 BHLHE22 CBLN1 CYP7B1 (the main SNP from this study maps to this gene) was previously flagged by @mariovitali: One person out of twenty from this study had a likely pathogenic variant in the same gene (Supplementary Table 1): A network medicine approach to investigating...

Genome-wide study of somatic symptom and related disorders identifies novel genomic loci and map genetic architecture [Line breaks added] Abstract Somatic symptom and related disorders (SSRD) are characterized by a mixture of neurological and psychiatric features and include functional...

The AI translations on the non-English songs are probably the best I can get without speaking the language myself, but if any native speakers ever want to correct any parts of the translated lyrics for these songs, I will make the edits.

Alaska Native News: 'Myalgic Encephalomyelitis Awareness Day To Be Recognized in Alaska'

Tommy Appelhoff - Unsichtbar (ME/CFS) - (Akustik Version) Also, piano/studio version of the same song:

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