Search results

Oh, so "C2_v2_england_controls" means "COVID-19 positive (controls include untested), only patients from centers in England". So they had a COVID illness but not everyone was confirmed with a lab test? I guess that means both groups were COVID positive and having both associations makes sense.

I think the second one should say 'Covid19:C2_v2'. But I agree, I can't think of what it could mean to be associated with both the controls and the cases for COVID (assuming that's what that code stands for)

That's interesting that the threshold lowering lasts longer than the symptoms for you. Maybe it does for me too and I haven't made the connection. I do remember that thread now. But even in this case, I think there are two ways to frame it: PEM is, after exertion, both the worsening of...

Multi-layered deep immune profiling, SARS-CoV-2 RNAemia and inflammation in unvaccinated COVID-19 individuals with persistent symptoms Roberta Rovito, Valeria Bono, Nicolò Coianiz, Valentina Cazzetta, Sara Franzese, Joanna Mikulak, Clara Di Vito, Francesca Bai, Guillaume Beaudoin-Bussières...

Cognitive impairment and associated neurobehavioral dysfunction in post-COVID syndrome Laura Marie Schmidt, Carsten Klingner, Insa Petersen, Annika Volkmer, Minne Schreiber, Alexander Schmidt, Philipp Reuken, Bianca Besteher, Christian Geis, Markus Ullsperger, Kathrin Finke, Eva Maria Martin...

Yeah, I can see how it could help others understand if it's mentioned. Increase in fatigue? So what, we all get tired. Increase in fatigue so bad that you can't leave the house or you stay home to prevent it from getting even worse? That sounds pretty bad.

I think 'reduction in function' makes sense as a part of the definition/description of ME/CFS since that's the syndrome that describes everything going on. PEM (disproportionate worsening of symptoms after exertion) is one of the aspects of the syndrome. Reduction in function can be another...

Yeah, I'm having trouble understanding what 'definition' means here. Something similar could be said for something like severe pollen allergies. Someone might reduce function (stay in the house) to not further worsen allergies. I can see how an enclopedia entry about pollen allergies could say...

Hmm okay, so 'reduction in activity' can be due to worsened symptoms and/or to prevent further worsening of symptoms. I guess I can imagine a hypothetical person whose only symptom in PEM is blurry vision. They are fully capable of continuing to do their job playing in an orchestra with blurry...

I guess I'm not understanding why 'symptoms' alone doesn't cover it. For one, inability to tolerate stimuli could definitely be described as a symptom (e.g. light insensitivity). But also, isn't the inability to perform an action wholly caused by the worsening of symptoms (fatigue, brain fog...

This seems like a circular argument. 'PEM' is included in the definition to explain 'PEM'?

Ah, I must have missed or forgot those discussions. I've just been considering the NICE definition as more or less the best we've got: But what exactly does 'function' mean? Objectively doing less activity while in a crash? Couldn't someone push through a crash if, for example, they have to...

Posts moved from Attention grabbing media for spreading ME/CFS awareness Yeah I thought some of them were okay though. But wait what is PEM if not a worsening of symptoms?

Thread: Film: This is ME (Festival edit), by Josh Pickup

https://www.hope4mefibro.org/discover-me-experience/

Persistent neurocognitive deficits in long COVID: Evidence of structural changes and network abnormalities following mild infection Bedia Samanci, Ulaş Ay, Haşim Gezegen, Sanem Sultan Yörük, Alpay Medetalibeyoğlu, Elif Kurt, Erdi Şahin, Faruk Uğur Doğan, Mehmet Barbüroğlu, Başar Bilgiç, Haşmet...

I saw that the next PolyBio Symposium was mentioned in the News in Brief, so adding here as well: PolyBio Spring Symposium Zoom seminar with 10 minute research updates from 33 researchers. Friday, May 16, 1100 ET / 1500 UTC Details | Registration ----- I was most interested in hearing updates...

Science: 'News at a Glance' "Blood pressure and dementia A trial of nearly 34,000 people in rural China offers some of the best evidence yet that reducing high blood pressure, alongside lifestyle changes, can lower risk of cognitive impairment and dementia. The study, described this week in...

Blood pressure reduction and all-cause dementia in people with uncontrolled hypertension: an open-label, blinded-endpoint, cluster-randomized trial Jiang He, Chuansheng Zhao, Shanshan Zhong, Nanxiang Ouyang, Guozhe Sun, Lixia Qiao, Ruihai Yang, Chunxia Zhao, Huayan Liu, Weiyu Teng, Xu Liu...

Apart from the HLA alleles associated with an increased risk of ME/CFS (mainly HLA-C*07:04 and HLA-DQB1*03:03), they discuss two that appear to have a protective effect (but not significant after multiple test correction): Interestingly, both of the ME/CFS risk alleles were found to be...