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323 - Toxic Exposures and Chronic Overlapping Pain Conditions in a Veteran Cohort: Gender-Specific Insights from the Million Veteran Program Armand Gerstenberger, Niloofar Afari, Marianna Gasperi [Line breaks added] Chronic overlapping pain conditions (COPCs) include migraine, tension...

368 - Relation of Immune Profile to Exercise-Induced Pain and Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-acute Sequelae of SARS-CoV-2 Infection Giovanni Berardi, Adam Janowski, Samuel McNally, Gregorius Bernhard, Alpana Garg, Kathleen Sluka Abstract Individuals with...

I've never heard of it. What's special about it?

GeneCards links and associated conditions for the 29 potentially causal genes, transcribed from figure 2: ACE - Alzheimer's, Schizophrenia AGER - Schizophrenia AMN - Depression ANXA1 - Autism APOC1 - Alzheimer's BTN2A1 - Schizophrenia, Depression, Bipolar Disorder CD40 - Schizophrenia...

Previously I had emailed one author about the list of genes. Today I emailed the other corresponding author, and they responded to say they'll have to look into whether they're allowed to share it. If they send me the list and give me permission to post, I'll do so.

Immunological drivers and potential novel drug targets for major psychiatric, neurodevelopmental, and neurodegenerative conditions Christina Dardani, Jamie W. Robinson, Hannah J. Jones, Dheeraj Rai, Evie Stergiakouli, Jakob Grove, Renee Gardner, Andrew M. McIntosh, Alexandra Havdahl, Gibran...

Sure, I added "lifelines study" since that's the tag used by other threads.

Familial coaggregation and shared familiality of functional and internalizing disorders in the Lifelines cohort Martje Bos, Rei Monden, Naomi R. Wray, Yiling Zhou, Kenneth S. Kendler, Judith G. M. Rosmalen, Hanna M. van Loo, Harold Snieder [Line breaks added] Background Functional disorders...

Identification of diagnostic biomarkers for fibromyalgia using gene expression analysis and machine learning Fuyu Zhao, Jianan Zhao, Yang Li, Chenyang Song, Yaxin Cheng, Yunshen Li, Shiya Wu, Bingheng He, Juan Jiao Juan Jiao, Cen Chang [Line breaks added] Objective Fibromyalgia (FM) is a...

It's unclear if all the participants had ME/CFS pre-COVID. If some of them developed ME/CFS as a part of long COVID, aren't all the COVID associations to be expected? The cohorts: The referenced 2023 study doesn't say whether the participants were pre-COVID ME/CFS.

I'm not really sure if it's been looked at much. I assume the data from DecodeME could be used for this. I just did a search for "genetic correlation" and ME/CFS and found that this recent preprint mentions it, though I'm not sure if the term means exactly the same thing in this paper...

I wasn't sure what the "rg" metric was. From Wikipedia:

Posted on behalf of @Utsikt.

The phenotypic and genetic association between endometriosis and immunological diseases Nina Shigesi, Holly R Harris, Hai Fang, Anne Ndungu, Matthew R Lincoln, The International Endometriosis Genome Consortium, The 23andMe Research Team, Chris Cotsapas, Julian Knight, Stacey A Missmer, Andrew P...

Good idea. I added a comment asking if they could upload the supplementary tables or provide the list of genes. I think MedRxiv has to approve the comment before it becomes visible though.

I emailed about the same thing! No response. The paper references a Supplementary Table 2 that should list the genes, but that's not on MedRxiv, so I thought maybe they forgot to upload it.

I wanted to make a thread with methods for finding out about new research right as it comes out. Google Scholar You need a Google account for this. If you don't have one, you can create one from the Sign In button at the top of any Google page. When signed in, on scholar.google.com, open the...

Thread for a paper on NLGN1 and risk of suicide: Genome-wide association study meta-analysis of suicide death and suicidal behavior (2022, Nature Molecular Psychiatry)

Discussed in another thread, World ME Alliance has a website for adding your photo to a poster with one of these six messages.

Research Digest | Issue 116 Welcome to the 116th edition of the Research Digest! In this issue, we explore emerging blood-based biomarkers for ME/CFS and share findings from a study highlighting the high burden of chronic overlapping pain conditions and their impact on health and quality of...