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Details of the outcome measure used - DM1-ActivC - is here: https://www.ncbi.nlm.nih.gov/pubmed/26484877 (Oh look - another subjective measure that changes by tiny amounts and is called significant - aargh!)

Cognitive behavioural therapy with optional graded exercise therapy in patients with severe fatigue with myotonic dystrophy type 1: a multicentre, single-blind, randomised trial Kees Okkersen, et al. Lancet Neurology - 19th June 2018 - Online First [Sorry - I'm having terrible trouble with...

If MS doesn't like ppl "endlessly banging on" about it, maybe he should ask The Lancet to retract it? Just a thought.

I'd also like to see a proper analysis of that - but we need the whole dataset - and the quantity of missing data is concerning. I've already had a cursory look at what we have, but I no longer have the proper software to do anything fancy. But I did produce this: The red dots that disappear...

I still think that without any valid objective measures, re-analysis is almost completely pointless, as it will only repeat the errors that were made during the trial. What is needed is an inquiry - one that has the power to contact and re-interview all the participants, to find out exactly...

Are there any "immune or metabolic treatments" that are commonly used in other countries for ME/CFS? I'm just wondering why they mentioned them at all, if they really do deny any involvement of immune or metabolic processes in the disease?

I tried to pin him down on what phrase he would prefer... (thread)

I think he's just trying to stir up conspiracy theories tbh. My guess would be that he simply didn't have time to be involved at any significant level, so he was happy to stay in the background and pull strings, oil the tracks, that sort of thing.

This from Wessely's book on Clinical Trials...

This is the main thing I asked about in my letter to RH a few months back - ie, whether it was appropriate for Knoop and Bleijenberg to write the commentary, and whether they had also peer-reviewed the paper. I didn't really get much of an answer.

In this case, yes. In the TSC minutes, editorial=commentary.

I guess by "trial equipoise", they are trying to indicate that they are not favouring any particular treatment over another, but I'm not sure they really had any control over their own implicit biases in that way. wrt to the prescriptions, I though it was interesting that they noted that there...

I've been saving screenshots of most of MS's tweets for a couple of weeks now. I can start on SW too if you like.

Just noticed this in TMG minutes #4, re withholding/excluding treatments specific to CFS: Thoughts?

This from the Contributors section of White et al 2011: "The centre leaders were BA, TC, Eleanor Feldman, GM, MM, HO, Tim Peto, MS, PDW, DW, and Simon Wessely." He is also listed as one of the SMC doctors. He clearly has a very poor memory.

Where exactly does he stand on this? I'm getting a very confusing picture here: Then in 2015: Linking benefits to treatment is unethical, and probably illegal https://www.theguardian.com/commentisfree/2015/jul/29/coercing-people-mental-health-problems-work-treatment How very Vicar of Bray!

How long before he torpedoes the ship?

Well, err, I was trying to provoke a denial, but I'm not sure anyone's listening (or going to talk). I suspect that Knoop and Bleijenberg reviewed it, but who knows whether we will ever find out. But what we do know is that the field has been clique-ified for decades - as long as the research is...