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Posts discussing the evidence for orthostatic intolerance in ME/CFS and potential treatments have been moved to the Orthostatic intolerance thread.

This was it.

I think it has been mentioned here previously that Wessely has talked about the dangers of too much awareness (I think in the context of overdiagnosing life events as depression)?

I'm mild/moderate (more on the moderate side the last year), and I struggle with this. It comes and goes, which it also did when I was mostly mild. It's worse when I've overdone it, and if I'm in PEM it's the worst. With my height/weight and activity levels, I normally don't need a lot of...

This makes me so mad! When we had about how neurological disease affects nutritional status, a number of potential problems were brought up: Inability to go shopping and/or prepare foods (Due to weakness, fatigue etc.) Inability to eat and/or digest food Nausea or lack of appetite These...

No, but I know of some patients that have been put into a higher priority group by their GP on the basis of their ME/CFS.

The PhD position? The Norwegian Research Council.

I might have misunderstoof the wording, when reading it again it only says PAEDIA "heads an international consortium of post-infectious cohort studies (COFFI -- Collaborative of Fatigue Following Infection, www.coffi-collaborative.com)". English...

A new phd position with PAEDIA/COFFI on the role of the immune system in long term fatigue following infection (the norwegian text says "chronic fatigue/ME", while the english one only says chronic fatigue).

I am not able to read these webistes outside uk, could someone post a summary? :)

When I hear "hope" now, I think about Recovery Norway and that is not a good association.

With vitamins/minerals that are part of many enzymes and/or reactions it would indeed be complex to figure out. I'd still expect to see some evidence of deficiency though, as in people with functional B12 deficiency - normal B12 levels (although commonly in the lower end of the reference range)...

That a disease itself causes loss of function does not mean it is not made additionally worse by being malnourished on top of the disease.

Another problem is that zonulin is expressed by other cells as well, and when you look at the serum you would not know if it comes from the gut or from say adipose tissue. The study I mentioned used an ELISA kit from Cusabio. I'm not familiar with it. I do wholeheartedly support more focus on...

I think it's pretty big many places, as zinc is part of many reactions and also an antioxidant. Very easy to market :P

In general, better nutritional status and sleep improves functioning in chronic diseases. I don't see why ME/CFS is any different. That said, giving people a supplement if they don't have a deficiency is rather pointless. Here they looked a blood zinc levels but they are not reported in any of...

Gliadin in gluten can change tight junction expression levels and/or localisation at the cell membrane by stimulating zonulin expression, causing "leaky gut". Increased zonulin has been found in non-celiac-gluten-sensitivity, and some (not all) patients have anti-gliadin antibodies, I think I've...

This one about cow milk protein: https://onlinelibrary.wiley.com/doi/full/10.1111/apa.13476

I haven't read the study, but elimination diets are the gold standard for food sensitivities. If symptoms reappear upon testing (preferably blinded) that is seen as proof of the sensitivity - and then you test again later to see if it has gone away. The symptoms listed could have many other...

"Believed to" is not exactly arguing for a strong evidence base ;) It's present in many conditions, if I remember correctly some studies on rodents have shown impaired gut integrity occurs before other signs of disease manifests itself, but that's not saying much and might not be relevant in...