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It seems another bad muddle to me. One of those quoted focuses on the S for syndrome but I see no evidence for there being a specific syndrome that is worth the name POTS. For sure there is POT - postural orthostatic tachycardia. People with that may also have other problems - some may have ME...

I think this is the study from Frances Williams that has been working its way towards publication since late 2019 at least. It is an important pointer to what might turn out in ME/CFS on GWAS. As far as I can see the methodology is similar to that already tried for ME/CFS using diagnosis or...

I am doubtful that it is worth setting up another GWAS study. If the UK GWAS study comes up with no genes I doubt further studies will find anything very crucial. If it comes up with some strong candidates then the next thing to do is targeted studies on those candidates. Repeating the expensive...

Yes, but 'gene expression' just means cells are doing something. It provides no other useful meaning. It is a pretension. If someone says 'altered gene methylation' then that is a bit more specific but gene expression covers everything active - metabolism, immune signalling, salt regulation -...

Genetic changes could be behind long-term COVID symptoms Even those with asymptomatic COVID infections could have long-lasting changes in genetic expression which could be behind long-lasting symptoms in recovered patients. This really is a complete muddle. This has nothing to do with 'genetic...

I am pretty sceptical of the significance of all this stuff. They might at least get what they say right - especially when there are two thousand authors to proof read it. The mAbs will have targeted viral and neural antigens, not anti-viral and anti-neuronal antigens. And lots of monoclonal...

Yes, I kept refreshing the page, hoping I was going to get my coffee on time! The total did not make sense in terms of what was coming up on the credits but then I discovered it did if one noticed that donations were popping up several places back in the list - presumably the list was in order...

'Vax-induced antibodies can eliminate the viral reservoir, and/or vax can reprogram autoreactive lymphocytes.' This doesn't look good immunology to me. I cannot see any reason why vaccine should eliminate viral reservoir through immune response if virus does not generate the immune response. I...

We have seen a speeding up of donations at the end of a crowdfund before but I get the impression that suddenly yesterday morning this one speeded up a lot. I wonder if for some reason word got spread wider through social media accounts and a whole new lot of people were reached? If so it may be...

I guess it must vary according to the method of payment or something. I noted that donations frequently appeared in the 'credits' not in strict temporal order - so that a donation would appear half a dozen names back and the total would go up by that amount.

No, it is because even if the site says your donation has been received it seems to take at least an hour for the money to show up on the tally. Maybe it has to be processed by your bank.

Who has noted her? Apart from her that is.

But it's not really a challenge, David. Some of us were born to want to rock boats without a financial incentive. Which is what makes life worth living.

Throughout my career I hardly ever got funding for worthwhile projects from formal sources. The important things are always funded on a shoestring, mostly borrowed from some other pair of shoes. One shouldn't be frightened by that but it is still necessary to play the game enough to be in a...

A remarkably elegant Tempranillo for a reasonable price recommended by Jane MacQuitty I think.

I am now going to raise a glass to everyone.

As someone with experience with immunofluorescence I would suggest being very wary of that. A positive result with three different organisms strongly suggests an artefact. Everything fluoresces with enough reagent. Immunofluorescent tests are only really meaningful if one thing is positive when...

So now the target is £22,500 by elevenses. More than half way there already.

Hasn't someone already posted this? CSF does not clear metabolic waste products from the brain as far as I know. This looks like typical misunderstood physiology - which is the common sort I am afraid.

This looks like an abstract for a poster presentation at a meeting. It also looks completely meaningless - being based on patients selected from a clinic that specialises in diagnosing people with these conditions, some of which probably do not even exist. It is just private medical marketing.