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  1. Jonathan Edwards

    A general thread on the PACE trial!

    Calibration Bypass Therapy - wouldn't that need a Hi-viz orange cardigan and hard hat though?
  2. Jonathan Edwards

    Psychosomatic medicine and the psychologising of physical diseases

    A number of posts have been moved from Guardian: George Monbiot 'Apparently just by talking about it, I’m super-spreading long Covid', April 2021 - Discusses ME/CFS and PACE I had an interesting and long conversation with a journalist a couple of days ago. She asked me if I was really saying...
  3. Jonathan Edwards

    Accuracy of Practitioner Estimates of Probability of Diagnosis Before and After Testing, Morgan et al, 2021

    Meaning These findings suggest that 'experts' are unaccustomed to using probability in diagnosis and clinical practice.
  4. Jonathan Edwards

    George Monbiot on ME/CFS, PACE, BPS and Long Covid

    Surely the situation is much worse. If writing about illness causes it then all the papers by liaison psychiatrists and their trials and grant applications and press releases must have been the cause of ME. They must have invented and caused the disease. Not that they did but that would be their...
  5. Jonathan Edwards

    George Monbiot on ME/CFS, PACE, BPS and Long Covid

    Seems to be a lack of imagination here.
  6. Jonathan Edwards

    George Monbiot on ME/CFS, PACE, BPS and Long Covid

    Fiona Watt at the MRC should read Monbiot's thread. I didn't bother to follow it up when she came out with the usual nonsense about PACE being OK. She is still in charge at MRC as far as I know.
  7. Jonathan Edwards

    Neutrophil Extracellular Traps

    I am afraid that this is almost certainly a half-baked idea based on artefacts seen in experimental systems. The basic idea that neutrophils are involved in trapping material at sites of damage is age-old histopathology. It is relevant to polyarteritis and things like meningococcal septicaemia...
  8. Jonathan Edwards

    Paul Garner on Long Covid and ME/CFS - BMJ articles and other media.

    I am sure these are not unusual. Meddling with people's ideas about their motives seems to me inexcusable. People regularly get told that their problems are due to early family life. That can very easily destroy the family. I grew up in a circle of North London left wing intellectuals that...
  9. Jonathan Edwards

    Paul Garner on Long Covid and ME/CFS - BMJ articles and other media.

    Maybe I should give a brief account of psychotherapy: my experience as a medical student. I did my psychiatry attachment in Oxford. I was asked if I wanted to treat a patient with psychotherapy. I thought I should try. I was given no advice on what to do or what the evidence was for doing this...
  10. Jonathan Edwards

    Paul Garner on Long Covid and ME/CFS - BMJ articles and other media.

    Isn't the story adding up all too clearly? One might ask why Garner went into infectious diseases rather than psychiatry. All that crosses my mind is that in those days (after TB and before AIDS) infectious diseases was a backwater nobody was very interested in.
  11. Jonathan Edwards

    Paul Garner on Long Covid and ME/CFS - BMJ articles and other media.

    Paul Garner of LongCovid fame qualified from UCL in around 1979, so yes.
  12. Jonathan Edwards

    Prevalence of (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care, 2011, Lacerda,Nacul

    Must have been a pretty weird sort of ALS. He was active until he was about 80 if I remember.
  13. Jonathan Edwards

    Prevalence of (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care, 2011, Lacerda,Nacul

    I have heard of nobody on the ALS list except Steven Hawking. On the ME list I have heard of David Putnam, Cher, Clare Francis, Susan Blackmore, Michael Crawford, Brynmore John, John Rutter, Ken Wilber.
  14. Jonathan Edwards

    Prevalence of (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care, 2011, Lacerda,Nacul

    I don't think so. The number of celebrities seems a pretty useless measure. The lack of conferences simply reflects the lack of any research programme because nobody has made much progress. I know a fewl people with ME through social contact - about the same as I do for MS and rheumatoid. So it...
  15. Jonathan Edwards

    No signs of neuroinflammation in women with [CFS] or Q fever fatigue syndrome using the TSPO ligand [11C]-PK11195, 2021, Raijmakers, Knoop et al

    I had not realised that Nakatomi had used cerebellum as a reference region. That seems troublesome because it means the study might be picking up differences in brain region usage within individuals rather than any absolute measure of microglial activation.
  16. Jonathan Edwards

    Paul Garner on Long Covid and ME/CFS - BMJ articles and other media.

    It isn't really even using the lay sense of benefit - which means an improvement attributable to... Whether the improvements are attributable to anything is the question in hand.
  17. Jonathan Edwards

    Paul Garner on Long Covid and ME/CFS - BMJ articles and other media.

    But his story is not just a lived experience. His lived experience was that he was ill for ages after Covid and then got better. His story is that he was ill for ages after Covid and got better once he started to think positively. "Lived experience' is always introduced as a bogus argument...
  18. Jonathan Edwards

    Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function after an Ind. Activity Prog, 2021, Newton,Morten

    I don't see that as a secondary purpose of research but as a self-interest of researchers. It is perfectly possible to stick to research that gets useful answers - as long as you (a) do not see research as an exercise in self-aggrandisement (b) you know what you are doing. Spending other...
  19. Jonathan Edwards

    Paul Garner on Long Covid and ME/CFS - BMJ articles and other media.

    No this is what serious philosophers spend their time on these days. The BPS people and politicians with funny hairstyles are not the only people to have lost the plot it seems.
  20. Jonathan Edwards

    Orthostatic intolerance

    Rowe may be open to exploring further, but this is still a haemodynmic explanation. In fact ALL haemodynamic explanations of OI assume that the effect is through reduced cerebral blood flow as far as I am aware. A low BP affects you by reducing cerebral blood flow. A tachycardia is supposed to...
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