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  1. Esther12

    Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

    Sorry - Missed this thread and started another. Will copy it over to here: Genetic findings in anorexia lead to questioning of link to perfectionism [Guardian article by the terrible Ian Sample] I've not looked at the original research (maybe this is over-hyped rubbish?!), and am just...
  2. Esther12

    BMJ Archives of Diseases in Childhood: ''Editor’s note on correction to Crawley et al. (2018)'', 2019, Nick Brown. (SMILE LP Trial)

    Maybe. But surely that would have shown up in their feasibility sutdy, prior to converting to a full trial. And if that was the case shouldn't they have reported it rather than claimed "that self-reported school attendance lined up very well with the schools’ records of attendance" [as reported...
  3. Esther12

    BMJ Archives of Diseases in Childhood: ''Editor’s note on correction to Crawley et al. (2018)'', 2019, Nick Brown. (SMILE LP Trial)

    Fair points, but some possible responses: Seems unlikely that all the individuals would say no - they already had ethics approval. If it was too much faff by the time they were converting their feasibility study into a full trial then that should have been reflected in the protocol for the full...
  4. Esther12

    BMJ Archives of Diseases in Childhood: ''Editor’s note on correction to Crawley et al. (2018)'', 2019, Nick Brown. (SMILE LP Trial)

    I guess she could say she was only talking about the data she had (what does she have?!)? If she was referring to some limited data, rather than outcome data for SMILE, in response to concerns about 'placebo' distorting scores for self-report outcomes then she surely would have known she was...
  5. Esther12

    BMJ Archives of Diseases in Childhood: ''Editor’s note on correction to Crawley et al. (2018)'', 2019, Nick Brown. (SMILE LP Trial)

    From Buzzfeed: https://www.buzzfeed.com/tomchivers/inside-the-controversial-therapy-for-chronic-fatigue In the original protocol : http://www.bristol.ac.uk/media-library/sites/ccah/migrated/documents/smprotv6final.pdf
  6. Esther12

    BMJ Archives of Diseases in Childhood: ''Editor’s note on correction to Crawley et al. (2018)'', 2019, Nick Brown. (SMILE LP Trial)

    Just to point out that there's a note listing the changes here (that I'd previously missed): https://adc.bmj.com/content/early/2019/07/11/archdischild-2017-313375corr1
  7. Esther12

    BMJ Archives of Diseases in Childhood: ''Editor’s note on correction to Crawley et al. (2018)'', 2019, Nick Brown. (SMILE LP Trial)

    It looks like the original version of the article is still available on PMC, and I archived a copy here in case it's useful: https://web.archive.org/web/20190711172758/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865512/ I tried to compare the text here ( bit of a mess - I had trouble getting...
  8. Esther12

    BMJ Archives of Diseases in Childhood: ''Editor’s note on correction to Crawley et al. (2018)'', 2019, Nick Brown. (SMILE LP Trial)

    It shouldn't matter whether or not the editor believes it was all an innocent mistake, what matters is that the BMJ should never have published it. "The process has additionally involved seeking assurance from the authors that the change in primary outcome was not influenced by (positive)...
  9. Esther12

    Trial By Error: Some Thoughts on MUS and Bermingham; My Letter to Professor Payne

    Nice one - that was a really clear explanation of this undeniable problem. I think I find the article style blogs easier to take in than the open letters, though I only realised that when I got to the letter section of this blog and felt myself having to work harder. By "Dawn Golder is...
  10. Esther12

    A general thread on the PACE trial!

    No. I think Bavinton is particularly rubbish though. I cringe whenever I read anything from her about research - she really doesn't seem to have a clue.
  11. Esther12

    A general thread on the PACE trial!

    Not interesting enough for a new thread, but Jessica Bavinton's Vitality 360 has a statement on the PACE controversy that says "we would like to address these concerns from the context of our position as experts in the delivery of rehabilitation programmes in this field" but then fails to...
  12. Esther12

    The Norwegian ME Association's report on severe ME

    What a nasty and bigoted view of the controversy from Helland. I wonder if she really believes that is the cause of the divide, or if she has decided to cynically stigmatise patients for raising concern about poor quality research that harms how they're treated? "Unfortunately some patients are...
  13. Esther12

    Want to learn about neurology

    A long time ago I read some pop-science neurology that I quite enjoyed, but I've since come to realise that a lot of what they said was rubbish. I'm afraid that leaves me without a recommendation for you. Good luck with finding something though.
  14. Esther12

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome' 2017, Larun et al. - Recent developments, 2018-19

    Not just Cochrane, but a lot of people in the field of mental health research/rehabilitation have got away with low standards for a long time, and have come to be viewed as 'independent experts' on what standards are appropriate. The idea that we should not be trying to raise standards is...
  15. Esther12

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome' 2017, Larun et al. - Recent developments, 2018-19

    I forgot they even explicitly claimed that the primary outcome was reported in accordance with the protocol. Why were these people ever allowed to publish their review?
  16. Esther12

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome' 2017, Larun et al. - Recent developments, 2018-19

    I missed that - from the Norwegian? I think I might have skimmed through these too quickly.
  17. Esther12

    Draft of New IDSA Lyme Guidelines

    I only saw one reference to medically unexplained symptoms in there, saying that more research was needed. At the moment there is a problem with people being told that their symptoms are a result of Lyme when there is not good evidence that this is the case.
  18. Esther12

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome' 2017, Larun et al. - Recent developments, 2018-19

    Also- good points about the missing documents. I don't really know how the Norwegian system works, but it seems something odd has happened there.
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