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Interesting. I was curious to know how it worked so had a look at the code: https://github.com/kosukeimai/MatchIt/blob/master/R/matchit.R It's a far too complex for me but if I understand the gist of it, the default is to use logistic regression, calculate predicted values and then find the...

This looks like a very successful grant round at the university of Vienna: The WWT and WE&ME Foundation provided funding for a call on Understanding ME/CFS of maximal 100.000 euros in funding per project. They received 13 applications and 7 were funded. These include research on severe ME...

The conclusion of the paper writes: Which I found rather confusing because the content of their paper suggest rather the opposite. Of 30 single nucleotide variants (SNVs) previously associated with CFS, only one was associated with subjective fatigue severity in the control group. The authors...

Quote from the review: In the discussion section the reviewers refer to ME/CFS:

I know but it's a bit weird to call for a NICE guideline to be withdraw on a topic that you have never published on, or have done any research on.

Jon Stone and Alan Carson have also signed that statement. I know they are FND experts but as far as I'm aware they have never researched or published about ME/CFS.

British birth cohorts suggested that psychopathology is a risk factor but there is uncertainty about diagnosis (e.g. diagnoses such as depression might have been for ME/CFS before it was recognized as such). https://pmc.ncbi.nlm.nih.gov/articles/PMC3078325/ https://pubmed.ncbi.nlm.nih.gov/17976252/

After treatment, 81.1 % of the sample still experienced clinically significant fatigue (score > 76) on the CIS-20 total fatigue score (range: 20-140). For the total group the mean score changed from 112 to 98. The SF-36 physical domain score went from 31.6 before treatment to 35.3 after...

Main results were: Most confounders did not have a significant effect on the risk of CFS. It was only a bit higher in females and slightly lower in young people < 18 years. Also noted that the risk was higher in those without depression versus those with depression.

Could be. I found that she was co-author of this paper that compared CFS activists to climate change deniers: https://www.nature.com/articles/529459a.pdf

Open letter from a group of sleuths regarding problems with editors/papers at the journal Scientific Reports. Dear Mr Graf, We are a group of sleuths and forensic meta-scientists who are concerned that Springer Nature is failing in its duty to protect the scientific literature from...

Thanks, I was thinking about something similar, offer like a short summary version of the article at the top with bullet points so those interested could move on to the full article. Perhaps also infographics to make the main message/conclusion easier to share on social media but that might be a...

Thanks! Others have said so before but I'm still not sure if it is a big enough problem to change my online name and domain/hosting which would be a bit of a hassle. Perhaps I should do a poll or something like that to see what most people think how much of a barrier this is. The initial idea...

Thanks for the nice suggestions but I think that will be something for the future, perhaps if I have some more confidence on the topics I'm writing about. The main goal now is to initiate debate about this in the online ME/CFS community (patients, advocates, clinician's and researchers) where...

Had a quick look but it also talks about multi-system dysfunction, POTS, JHS, hEDS, testing NK cytotoxicity, recommends GET and CBT and suggests trying older antihistamines for sleep. It includes some interesting observations but not sure if it is that much better than other educational...

Twitter summary: 1) New blog post on hypermobile Ehlers-Danlos Syndrome (hEDS) and hypermobile spectrum disorder (HSD). https://mecfsskeptic.com/heds-and-hypermobility-spectrum-disorder/ 2) Epidemiological studies show no clear relationship between hypermobility and symptoms such as chronic...

A new blog post on the problems with hEDS and hypermobility spectrum disorder. https://mecfsskeptic.com/heds-and-hypermobility-spectrum-disorder/ Epidemiological studies show no clear relationship between hypermobility and widespread pain. This questions the validity of diagnoses such as...

Do not want to divert the discussion too much, but what this truly the case? I got the impression that only the coroner believed this because the physicians involved in her care tried to argue that nothing more could be done (to get themselves off the hook). They seem to hold a psychosomatic...

I don't see it this way. I suspect fibromyalgia is much older than the central sensitisation theory and that many FM researchers do not subscribe to this theory even it is the most popular one. There's also a 'central sensitivity syndrome' diagnosis that is much broader than FM. I think that is...

Thanks very much for this useful paper. I understand correctly, Dr. Souhami’s asked about the justification for differentiating ME/CFS from idiopathic fatigue or other unexplained symptoms. Here are my thoughts. Since very few physicians diagnose ME and other case definition have fatigue as a...