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In the NASA studies using complete bedrest it happened rather soon. From memory: I think most of the change happened in the first days and the blood eventually volume dropped by amount of approximately 10-15%.

Anyone heard anything about PEG-J, PEJ or jejunostomy being considered (i.e.placing the feeding tube directly in the stomach or intestines): were these tried and not tolerated? I find it strange that the discussion seems to focus on a nasal tube (problematic because of risk of aspiration and...

Surprising result. The controls had an infectious disease as well ('Our study design required an acute infection prompting COVID-19 testing') so that may explain the lack of difference between the groups. Nonetheless, the prevalence of ME/CFS-like illness was quite low, as the authors note:

"The FABQ, although originally developed for low back pain, has later been evaluated for other populations and is now widely used. Several studies have showed that the FABQ, particularly the work-subscale, is a good predictor of future work outcomes, and is thus much used in the clinic and in...

Abstract Study design: A cohort study with 12 months of follow-up. Objective: To assess (1) the unidimensionality of the Fear-Avoidance Beliefs Questionnaire (FABQ) and (2) whether single questions in the FABQ predict future sickness absence as well as the whole scale. Summary of background...

They argue that the optimal R&D investment in Germany was €676 million, which represents only a quarter of the total investment needed to bring a drug to market. They therefore say that international collaboration is necessary. A closer look at their assumptions: - The data on quality of life...

I think these authors have published more dan a dozen of these risk factor papers for CFS based on the Taiwanese insurance research database with a separate paper for each risk factor. I have doubts about the reliability of their database: it is unclear if ME or CFS are recognized diagnoses in...

Noticed that this researcher: Douglas C Youvan has written a comment/editorial on the finding. Maybe it will be published somewhere in the future? Perhaps also the reason why the study was featured in The Times...

Merged thread Am afraid this landmark study featured in the Times article is just the pilot study discussed here

I'm afraid they are referring to this study by the Griffith team, which does not seem lik a landmark study at all: Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants 2024 Marshall-Gradisnik | Science for ME (s4me.info)

Scientists say soldiers suffering from mysterious symptoms since the 1991 war are likely to have been exposed to hazardous biological and chemical agents. Full text at: https://www.thetimes.com/uk/defence/article/cause-of-gulf-war-syndrome-identified-in-landmark-study-v585cltjx By Larisa Brown...

It seems that they mostly focus on medical students. So if they use something like the IOM report, Mayo review article, NICE guideline or just the Wikipedia page on ME/CFS it would likely be much better than what most medical students learn about ME/CFS (if they hear anything about it all).

Thanks for sharing. Maybe they can do an episode on ME/CFS? Did a quick search and noticed that none of the team members is an actual doctor or specialist. Zach Murphy, the CEO and guy in the videos is a physician assistant.

Does anyone know more about this @Dakota15 ?

Anyone else had a look at this?

This paper also reports: Post-exercise depression following submaximal and maximal isometric voluntary contraction - PubMed (nih.gov)

By the way: reference 19 is from the same research team (Samii et al. 1997. In this study they tested the amount of exercise needed to induce post-exercise depression in healthy people. Again, it seems that this refers to MEP done during the recovery phase, after exercise ended. The set-up is...

The graph reports the slope, so I assume this refers to the change in Dimitrov Index (DI) values, not the values themselves. So I don't think we know if ME/CFS patients had a higher DI at the beginning.

The description for figure 4.c (the one above) is also a bit confusing: For the graph on the slope of the Dimitrov index (Figure 4.B) they used: 'the first block (b1), the last block prior to fatigue onset (bn), and the first three blocks after fatigue onset (f1, f2, and f3)'. For Figure 4.C...

Had a look at the results on Motor Evoked Potential (MEP) which is an electrical signal generated in the muscles following stimulation of the brain.The authors tested this during the 30s rest blocks between exercises and describe the result as follows: Reference 19 is not about post-exercise...