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Looks alright for an exploratory analysis like this. They also used a Bayesian analysis where the results of Hanson study (German et al. 2022) on 220 metabolites were used to construct the prior for this study. This means that these metabolites were more or less likely to be statistically...

Some previous studies focused on c4a but results were not entirely consistent: Complement activation in a model of chronic fatigue syndrome - PubMed Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and...

Here's what this paper says about this:

Wrote a short summary, highlighting some findings: 1) An impressive dataset on ME/CFS was just published by the research team of Ian Lipkin. They tested multiple proteins and metabolites in 56 ME/CFS patients and 51 controls before and after exercise and cytokines in response to mimics of...

Noticed this thread on Twitter which may be useful to merge data with different names for the same gene ID. https://threadreaderapp.com/thread/1948378934967758920.html

Not really convinced by the arguments in this article. Reinfections and PEM from travelling to the site would affect both the placebo and treatment arm, so wouldn't explain the lack of difference between them. Participants were required to have GPCR autoantibodies, similar to the Erlangen...

Social media summary: 1) The Bragée clinic in Sweden published an uncontrolled study to test if intravenous saline improves symptoms in ME/CFS patients with dysautonomia. 2) This is an interesting question because salt solutions that go directly into the vein are often used as a placebo...

Shouldn't the paper also mention that Jeff Wood did/does paid consultancy for people with ME/CFS who think they have CCI as a conflict of interest?

Interferon gamma seems relatively normal compared to controls.

Made some comments about it here:

For other outcome measures they used Tukey's post hoc HSD but for the cognitive testing they used a linear mixed-effects model where it isn't clear if they corrected for multiple comparisons.

The authors used percentage difference scores from visit 1, which often makes the analysis more sensitive to outliers (e.g. participants who had a very low score to start with, could improve by 80-100%). So it would be interesting to check if the results hold up if they used the absolute scores...

I think there is clearly no effect for fatigue or physical functioning, but the scores on the cognitive test (the DANA Brain Vital) do seem to show an improvement in the treatment group compared to controls.

I agree with these comments. There is a risk that this ruling will make things worse because it seems to overvalue the use-case of these tests. I reinforces the idea that you need to have objective abnormalities in order to be able to receive disability (which for some diseases is almost...

We've finally changed our name on social media to 'ME/CFS Science'. The main reason is that we kept getting people who were upset by our old name 'ME/CFS Skeptic', thinking that we were skeptical of ME/CFS rather than claims made about the illness. It's a bit generic but hopefully the content...

I already have a list of topics I would like to analyze and write about and not enough energy to do them all, unfortunately.

Social media summary: This brain scan study from Australia found differences between...

Question: has anyone made an overview of publicly available dataset on ME/CFS? For example a list with links to papers or repositories where the ME/CFS dataset is available and can be downloaded by anyone, perhaps classified by topics such as immunology, metabolomics ..., etc.?

I suspect it refers to the physical component score. The Sf-36 different subscales are grouped into a physical component score (PCS) and a mental component score (MCS). PCS is calculated from: Physical functioning Role limitations due to physical health Pain General health MCS is calculated...

Made this social media summary of the study: 1) Scientists from Oxford University used one of the most powerful brain scans (7 tesla MRI) and found different results for ME/CFS and Long Covid. 2) In the 24 ME/CFS patients, there were increased levels of lactate in the anterior cingulate...