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    Preprint Understanding Neuroinflammation in Post-COVID-19 Syndrome: Biological Mechanisms, Diagnostic Biomarkers, and Therapeutic..., 2025, Martins et al.

    This is one of the creepiest things about the whole situation imo. It is never mentioned in the glowing discourse around him unless its skirted over.
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    How should biological researchers present their results about ME/CFS to the media - discussion thread.

    This is the thing I find most chilling about modern medical culture. If you throw a stone you hit a story of someone who's cancer or stroke or MS or whatever was missed because their doctors slickly dismissed their concerns and didn't do the necessary tests. So it isn't just us that bear the...
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    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    When your theories have been unquestionable in medical discourse for decades any dissent is going to feel like a personal attack. And the thing is no matter how politely we dissent, we are still saying that their entire career is built on a house of cards. Of course the stigmatising and...
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    Reddit - Interesting posts on Reddit, including what some doctors say about ME/CFS

    Well, I clicked on this thread without thinking and I now want to be sick. I cannot say this strongly enough: this attitude is the reason I am severely disabled. This prejudice and the weird culture of silence and patient manipulation it creates are the reason my GP thought the way to help me...
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    UK: All Party Parliamentary Group (APPG) on ME news, 2020 onward

    Just watched Chris Ponting's presentation. He seemed genuinely angry, and quite right too. A very good speech in my opinion and always very glad to have him in our corner.
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    Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS - Haukeland University Hospital

    I suppose the money will have to come from the Norwegian government or from charities/fundraising then.
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    Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS - Haukeland University Hospital

    That's disturbing. So they don't stand to reap a sustained profit if it works because biosimilars might flood the market in a few years?
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    Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS - Haukeland University Hospital

    Moved posts Do drug companies typically provide the drugs these sorts of experimental trials? Iirc for your RA rituximab trial you had to buy it yourself. I am thinking of the Daratumumab phase 2s struggle to get funding, and wonder if Janssen might be more open to persuasion to discount the...
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    Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS - Haukeland University Hospital

    I think this is a situation where it is frustrating that the forum hasn't got a 'direct line' to a lot of researchers. It would be very useful to know what F&M have already tried, ditto whether RD can be useful here. This feels like such an open goal for pharma/govts funding wise it's so...
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    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    You have said before that the 'hypothesis destroying' experiments that can total your hypothesis and help you build a better one might be drug trials in this scenario. Without speculating on what the drug would be, how might such trials play out? I'm interested in the mechanics and organisation...
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    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    I know Ron Davis' team were doing this kind of work with medical records regarding potential drugs.
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    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    The issue is that the recent piece on Simon Wessely was front loaded with so many poorly evidenced claims of irrefutable biological evidence that left the following discussion (which to be honest I only skimmed but it looked much better) of Wessely's many misdeeds vunerable to easy attack from...
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    Patients with severe ME/CFS need hope and expert multidisciplinary care, 2025, Miller et al

    Is it possible they have caught wind of the same developments JE has and are trying to accumulate enough 'evidence' to flood the zone with and drown e.g. news about DecodeME results out? Or am I overthinking things?
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    Patients with severe ME/CFS need hope and expert multidisciplinary care, 2025, Miller et al

    As in, AI will look at the most viewed articles/papers online to compile it's search results? If that's their move it's chilling. Honestly I've said this before and I'll say it again: the psychobehaviouralists behave like people who know their therapies don't work and are desperately trying to...
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    Who is Simon Wessely?

    Don't forget 9/11 emergency responders/survivors.
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    Who is Simon Wessely?

    Honestly I'd be much more offended if he had. At least he's not pretending to care about us while collecting his latest honour for throwing us to the wolves.
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    Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS - Haukeland University Hospital

    I agree, I feel like the UK MEA could redeem itself somewhat by reaching into it's coffers for this. OMF raise a lot of money too. You would think that this would be a priority for the community internationally. If it is discovered how to donate for those outside Norway I would be very...
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