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Studying mild/moderate people as the default. There may be signals in blood or tissue that are much more clearly expressed when people become severe.

My ME was originally mild and quite stable, bouncing back from massive exertions like finishing a master's degree, helping my partner through surgery, massive drinking binges and the exertion and withdrawal that came with it, head injuries etc (less proud of the last two haha). But after doing...

First, they came for the Musk apologists.... Honestly, this isn't even surprising. I saw this in the wild on Bluesky and thought 'sure, that tracks'. PACE was a political act motivated by ideological hatred of the disabled and chronically ill. It was a political decision to reduce the benefits...

This is the most dangerous lie they tell, at the core of it, and it's one people want desperately to believe, both about themselves and others.

Very good points. Honestly I thought before I got sick it was just humanities academia that was messed up like this. In lit academia people have to teach and publish so much they don't even have time to read the books they need to to advance their research. Terrifying that it's all science too...

Why would they publish a review nearly 2 years after their finding came out if they'd given up and moved on to other things?

I agree, that bothered me.

It's not what I was hoping for when I saw Hwang's name listed as author but this shows that they are still working on WASF3 and making an argument for its relevance! Hwang never replied to the email I sent him last year so I thought maybe we weren't going to hear any more about this finding...

I was not aware of this and am horrified but not particularly surprised. This should have immediately disqualified him from running PACE. It's such a massive and obvious conflict of interest. But PACE was so clearly about getting one particular answer and bending the data to that end. How many...

He and his colleagues e.g. Sharpe etc have saved medical insurance companies untold millions by giving them a pretext to deny claims from pwME and LC. He has done similar for the state, and does similar whenever there is an environmental pollution or mass poisoning or 9/11 or whatever where...

'Diseases associated with FYN include Wiskott-Aldrich Syndrome' From the page about FYN. A possible link with WASF3?

Does anything replicate here from the other genetic studies we've seen recently?

If you have a moment, can you explain more about what this means/would entail please? Thanks.

At the end of the UnitetoFight talk Das says that clinical trials will begin after replication on the LOCOME project (with DecodeME data) is complete! At Metrodora in Salt Lake City. I guess it remains to be seen how much of this is hot air but it's certainly exciting!

Just found this thread quite informative/refreshed my memory. https://www.s4me.info/threads/genetic-risk-factors-for-severe-and-fatigue-dominant-long-covid-and-commonalities-with-me-cfs-identified-by-combinatorial-analysis-2023-taylor-et-al.34243/#post-484434 Also found this video from...

Are any of these findings viable drug targets? I would have thought it was far too early for anything like that but very happy to be wrong. Their ME/CFS press release from last year claimed that they had identified viable repurposed drugs iirc but I don't think they've ever expanded on it...

So from what I can understand, they are claiming this is a replication of an earlier study, which seems like a big deal. And again Precision Life are talking about drug targets and repurposed drugs. Have they ever been specific about these in LC or ME? I would be interested to compare this to...

https://www.medrxiv.org/content/10.1101/2025.02.04.25320937v1.full.pdf+html New Precision Life preprint that was shared by Chris Ponting in Bluesky today. Looks very interesting.

Surely that is a model of the itaconate shunt, which is obviously a valid theory but has never been proven in ME, so even if the model is accurate to humans it may be of no use.

That's why I was fascinated by the muscle on a chip abstract that was doing the rounds a little while back. Similar thing but with lab grown muscle tissue or something similar rather than mice.