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A question - what experiments do these data and the Zhang study, Fluge and Mella's recent paper etc suggest might be worthwhile that could run in parallel with SequenceME? Be it lab work or theraputic experiments or biopsies or autopsy studies. Anything that would be worthwhile that doesn't need...

Could this be a possible explanation for or clue as to the horrendous gut issues in more severe ME/CFS

In the interview with David Tuller that came out today, Chris Ponting says this gene is involved in suppressing the immune system, and therefore if it went wrong it could cause many things to go wrong. I'm sure this is a (justified) oversimplification, so what is the more complex story?

Oh this is interesting. So you think the DecodeME results might have put paid to your hypothesis? Would we have definitely seen genes related to IFNG if it was involved, for example? Are T cells 'safe' from this thought exercise or would they have been likely to have had genetic 'hits' as well...

Interesting and perhaps frustrating that he is still hot on antiviral therapies. I'd love to be proved wrong but I just think if that was the answer we would probably know by now.

Do we know if you can text in to LBC ahead of time? I have written a message because I wont be able to phone in. Otherwise I'll send it at 7pm sharp.

In a sane world it would be the other way around. You would rule out ME/CFS if you suspected depression.

Sums up the hypocrisy of the psychobehaviouralists pretty succinctly imo

I think if anyone's up to the task of recruiting that cohort it's the Edinburgh team.

Yes! Interested to know what the rationale was but I think side by side comparison of ME and LC like this could be very valuble.

The long covid aspect of SequenceME seems to be new since the announcement if I'm not mistaken?

How do we progess from where we are now to drug targets and treatment trials?

Does this have similar methodological issues to the other recent Moreau paper?

I have always been prone to both catching colds and getting infections in cuts and scrapes

Again, a lot like humans!

Some of these posts have been moved from the DecodeME preprint thread. Yeah LLMs are very good at confidently spouting bollocks.

Well the AI is really raining on my parade today! Lets hope its confidently incorrect on that front (not that I expect a drug tomorrow, nice as that would be...) It's weird though, I searched the preprint for drug, treatment and theraputic and only really found this phase claiming that the...

This is a very good point.

And, it seems, large meticulous genetic studies can be ignored also. Facinating what it's possible to ignore if your faith in the almighty psychobehavioral paradigm is strong enough. Almost inspiring.

Yes I think they are trying to hold back the tide by painting this study as much more insignificant than it is, saying 'well we are still light years away from having any idea what is causing this' etc...