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  1. Sean

    Guidance for best practice for clinical trials, World Health Organisation, 2024

    -Failure to account for placebo effects Failure to account for heterogeneity in different confounders being lumped together under the placebo banner. Plus some repetition. But otherwise a useful list.
  2. Sean

    Neurodevelopmental and personality traits of somatic symptom disorder: A cross-sectional study 2025 Shimizu et al

    Did they test if the correlations are with being online, and willing to take part in online health surveys?
  3. Sean

    Opinion Conceptual competence in medicine: promoting psychosomatic awareness in clinics, research and education 2025 Dirk von Boetticher

    Proof: Death comes to us all. With no exceptions. Cue some twit trying to argue it is only because of culturally ingrained expectations of death.
  4. Sean

    Identification of a multi-omics factor predictive of long COVID in the IMPACC study, 2025, Gabernet et al.

    And intra-personal? i.e. dynamic/transient but still significant & relevant changes in the body? Could that be a confounding variable? Appreciate your feedback and engagement here. You will not find a more motivated group to find the correct explanation and best therapies (or at least...
  5. Sean

    Central sensitisation theory - discussion thread

    The cause of your pain is your pain. So just stop doing the pain and your pain will go away. Also effective on cancer, poverty, sexual harassment, flat feet, and acne.
  6. Sean

    Thesis A thesis of clinical research and practice [psychology and Long Covid], 2023, Petker

    it would be of clinical importance to seek to understand the resistance towards psychology that appears to exist within members of this patient group. Failure to understand and overcome this resistance could create barriers in reaching the patient group and implementing psychologically informed...
  7. Sean

    UK House of Lords/ House of Commons Questions

    To support clinical leadership in this area, NHS England has worked in partnership with the British Society of Physical and Rehabilitation Medicine What could possibly go wrong?
  8. Sean

    ME/CFS Skeptic - How many scientific papers are fake?

    Indeed. A general lowering of methodological standards, in particular inadequate control, is the broader picture.
  9. Sean

    Has there been a review of ME/CFS treatment randomised trials since the NICE 2021 review?

    Randomisation is just one of the means to control. A very important one, that should be used wherever possible. But not enough on its own. There still needs to be adequate blinding and/or objective outcome measures used as well.
  10. Sean

    Has there been a review of ME/CFS treatment randomised trials since the NICE 2021 review?

    Or award points for good one, none for a mediocre one, and negative points for a bad one.
  11. Sean

    UK: Disability benefits (UC, ESA and PIP) - news and updates 2024 and 2025

    Ministers have left the door open to a humiliating U-turn After an unnecessary, entirely self-inflicted, and long overdue humiliation. Good. Time they got some serious backlash against this endless naked cruelty against the sick, disabled, and poor. The fact that they thought it was a good...
  12. Sean

    United Kingdom: Dr Suzanne O’Sullivan (BPS neurologist)

    There’s enormous subjectivity in diagnosis, Oh, the irony. Yep. No coincidence at all. Infinitely flexible, infinitely adaptable. The God of the Gaps in medicine. All because they cannot simply say: We don't know.
  13. Sean

    United Kingdom: National Health Service (NHS) news

    In my experience of this world 'radical overhaul/reform' almost always is a cover for cost & service cuts. Rarely ends well.
  14. Sean

    How to read while lying completely flat?

    In my experience text-to-speech is very useful in shortish bursts, and I am grateful for it. But it is not so good for extended reads. It gets very drone like and relentless, almost oppressively at times, as it lacks the normal semi-random variations in tone and pace and rhythm found in...
  15. Sean

    Characterization, Treatment, and Long-term Follow-up of Fatigued Patients in Primary Care (iFAS), Lindsäter et al

    As I have been saying for years, psychosomatics has become a cult, and like all cults they are openly hostile to critics and criticism, and will actively reject and suppress all criticism, especially informed accurate criticism. And the more informed and accurate and persistent the criticism...
  16. Sean

    Neurometabolic network NMetNet for functional neurological disorder in children and adolescents, 2025, Lan et al.

    CONCLUSIONS These findings suggest that FND is characterized by dysregulated bioenergetics and increased vulnerability to oxidative stress. Understanding NMetNet in FND offers novel insights into the disorder’s neurobiology, with implications for therapeutic interventions to restore energy...
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