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  1. Sean

    [Book] ME/CFS and Long Covid: Diagnosis and management of chronic fatigue syndromes, 2025, Spickett

    Graded exercise is no longer routinely recommended. NICE explicitly recommended against it.
  2. Sean

    Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trials, 2025, Chang Tan et al

    Seems like shameless lying and self-promotion is the main requirement for prominence in medicine these days.
  3. Sean

    Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trials, 2025, Chang Tan et al

    Which is very close to the figure NICE reported. Hence any therapy recommended by the review has a high risk of harm.
  4. Sean

    Review Migraine and functional neurological disorder (FND)—a review of comorbidity and potential overlap 2025 Stone et al

    highlights converging frameworks of dysregulated allostatic/stress responses in the context of predictive processing models of the brain. :rolleyes:
  5. Sean

    Medical narcissism

    Psych diagnoses/attributions by clinicians usually tell us more about what is going on inside their heads then in their patients heads.
  6. Sean

    Functional and internalizing disorders co-aggregate with cardiometabolic and immune-related diseases within families: ... 2025 Steen et al

    Functional disorders share familial risk with internalizing disorders such as generalized anxiety disorder and depression, So, after the GWAS results the relevance to us of the 'functional' label is...? Functional disorders (FDs) such as fibromyalgia (FM), myalgic encephalomyelitis/chronic...
  7. Sean

    News from Germany

    She stresses psychotherapists’ limits: if biological and social needs were met, little would remain for her discipline to address. Grande gets it. This sounds like an article that would be worth translating in full.
  8. Sean

    Criticisms of DecodeME in the media - and responses to the criticisms

    I never said ME is FND, What about CFS? Is that FND? Just so we are clear.
  9. Sean

    Maeve Boothby O'Neill - articles about her life, death and inquest

    And behave very much like a cult.
  10. Sean

    Maeve Boothby O'Neill - articles about her life, death and inquest

    And yet the threat of these accusations and their appalling real world consequences continues on to this day. Their words are hollow, insulting, and cruel. And utterly gutless. It is beyond dispute that the profession, in cahoots with government, is completely incapable of facing up to the...
  11. Sean

    Criticisms of DecodeME in the media - and responses to the criticisms

    It is arguable that the lack of genes known to be linked to depression and anxiety is evidence in favour of any depression and anxiety being secondary reactive consequences of primary physiopathology, combined with huge secondary losses caused by both the disease itself, and serious...
  12. Sean

    Criticisms of DecodeME in the media - and responses to the criticisms

    Ask him about assessing treatment outcome by questionnaire, which is the preferred method of the psychosomatic/FND club. He might come to regret opening that can of worms.
  13. Sean

    Criticisms of DecodeME in the media - and responses to the criticisms

    This. "...because they are never placed in such a situation." And they make damn sure of it.
  14. Sean

    Can Large Language Models (LLMs) like ChatGPT be used to produce useful information?

    I don't know how accurate those two AI statements above are (1, 2), but they seem to me clear and concise, which is always a big plus, if for no other reason than that makes it much easier to spot the limitations and flaws. It demonstrates what I have long thought is the main potential benefit...
  15. Sean

    Criticisms of DecodeME in the media - and responses to the criticisms

    It is all marketing. His underlying belief about ME/CFS being a psycho-behavioural problem has not changed one bit, since his first comments on it in the formal literature back in the mid-1980s. Don't listen to what Wessely claims to believe, look at what he actually does, very consistently.
  16. Sean

    Criticisms of DecodeME in the media - and responses to the criticisms

    Wessely is just pulling his usual ex cathedra act. It is true because the Great Man said so. Accountability is coming, Sir Simon, and there is nothing you can do to stop it. And you thoroughly deserve it. You have been a deeply malign influence on this world, and have caused immense and...
  17. Sean

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    I strongly suspect that the undiagnosed or misdiagnosed rate, especially among the milder end of the spectrum, is going to be an important confounder in general. Nor would I be surprised if a decent chunk of that 'misdiagnosis' in particular was from wiser and more compassionate clinicians...
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