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Not necessarily, especially if we are looking at highly specific viral reservoirs. It could be a combination of agents, and why some get sick and others do not goes back to the right combination. These are great points @jnmaciuch. I also agree we are looking at several different pathogens...

My understanding is viruses and bacteria can infect neurons directly. Herpes and borrelia, respectively, would be examples.

Perhaps "diseased" brain would be more appropriate than damaged, although I'm not sure why. My wife damaged her hand when she broke a couple bones in it, but over time it healed and is no longer damaged.

But I fear the brain isn't normal in many pwME. From head pressure and headaches to issues with balance and gait to deficits in multiple cognitive domains, we can sense our brains are in many ways not normal (makes me think of the Mel Brooks line Abby Normal). Does the fact that we have wild...

But it sure can feel that way at times. I wouldn't discount some brand of damage simply because our technology is not up to snuff. Personally, I'd like to see more SPECT efforts, but that seems to have fallen out of favor since the turn of the millennium. Don't know why that particular spigot...

Great blog @Simon M . Thank you. Perhaps someone can help my confusion. I see references to these 8 aberrant genes "causing" ME/CFS. Is that literal? I mean, do these genes create what we call ME/CFS? Do they make us more susceptable? Does everyone have them, but they need to be"switched on"...

Sorry, I've deleted it. Thanks for putting up a better link.

I'd be curious where PTLD fits within this umbrella, or if it even does. If it doesn't, where does it reside? As a disease vs syndrome?

Other prior studies suggest persistence as a factor. Wonder why I feel the influence of a rheumatologist in this. Wonder which group from Johns Hopkins. Oh, and why is someone from AstraZeneca out of the UK involved? As they do in the various stages of Lyme. So I think this could represent a...

Mentions Long Covid and Fibromyalgia.

This is a fun conversation, but I am taking up too much oxygen in the room and for that I apologize and will stop.. I'm not sure much of the ME/CFS paradigm aligns with any known duck relative to many of its symptoms; this may also hold true for neuro aspects. There is precedent for this as...

Yes, to both @Trish and @jnmaciuch . These observations may be spot on. Our deficits may be temporary, they may be rooted in different mechanisms than in other manifestations of cognitive difficulties. All I am saying is that the cognitive deficits that appear in some pwME are cognitive...

Agreed. So you (and he) are suggesting our intellect is intact, but we have "distractions" that seem to inhibit or impede what would otherwise be a fine-working intellect? Have I got that correctly? This seems unnecessarily convoluted. Wouldn't a simpler explanation be that something is...

I'm struggling with this arithmetic, so please bear with me. On the one hand we have pwME, some of whom experience more pronounced deficits in intellect. But they don't disassociate, they don't hallucinate, their cognitive problems are more or less limited to executive functions, to things...

We have so many symptoms, but there is no standard intensity with which we all experience them. We are all unique in terms of how each symptom manifests. This is true in terms of duration and frequency and intensity. It's true for what triggers PEM, too. I think pretty much all pwME understand...

Some pwME have intellectual impairment. If anyone is going to characterize our disease, this fact in my opinion should be part of the characterization. What should not be part of the characterization is saying there is no intellectual impairment among pwME. That would simply be incorrect and...

People with ME share core diagnostic requirements. Things like unrefreshing sleep, PEM, OI, etc. They all have these factors to varying degrees. Same is true for things like balance or pain or exhaustion. Some people are in so much pain they can think of little else. Some people are so exhausted...

Merged conversation This smacks of opinion but it is framed as fact. Please remember this is a science forum.

FYI, purportedly there is acquired periodic paralysis. This is - as is the case with typical pp - supposedly temporary or intermitant. Not much, relatively speaking, is known about it because no money is thrown at it because it effects so few and, for the most part, we are a selfish and...

Alternatively, they could offer support for proximity playing a role in familial clustering of ME/CFS. I have not read the entire paper, and really don't want to revisit XMRV anyway....