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My uninformed guess is that any disease that causes enough of the symptoms that fall under the sundowner label can be said to cause sundowning, but I suspect that is just lazy semantics. I think there is simply symptom overlap between discrete diseases, and for brain symptoms that worsen as the...

The operative word here is "includes". Sundowning refers to a spectrum or collection of symptoms, none of which is definitive or universal - at least as far as I understand it. It doesn't necessarily include any. But the symptoms deal with the brain, and they become amplified as the day wears...

Outside of late-day patterns, would we be able to distinguish between the two conditions amongst those of us who are best in the mornings and deteriorate as the day progresses, as opposed to those of us who improve as the day unfolds? Is there a tie between cognitive exertion and PEM, and - in...

It's winning the slots with the right combination. Or perhaps more appropriately, the trifecta. I'm not convinced it involves predispositions, though. I would not rule out a combination of the right microbes, one or two of which fall beneath most radar.

Kenneth Liegner made news with this five or six years ago: https://pubmed.ncbi.nlm.nih.gov/31151194/

It's always nice to see fresh TBD research. This one seems to resurrect the decades old debate over whether non-viable Bb cells or remnants can cause disease. There are plenty of arguments for both sides, and many are based on far more sophisticated subjects than mice - like monkeys and dogs...

I too was concerned. I not only remembered my premorbid IQ scores, I ordered a copy from my old high school as a guardrail against my increasingly suspect memory. Over a span of 5 or so years, I had four new IQ tests. Turns out my concern was warranted; my IQ had dropped 15 to 20 points. I...

I have POTS - tachycardia and rising BP within 10 minutes etc. But I think my most unpleasant OI symptom is loss of balance. This also translates into gait issues. It feels like I'm about to tilt over so much I may fall, but I seldom do. I try to lean against things when ever I can when I walk...

In theory only. And when it comes to medicine, pretty much for the idealogues only. In reality, particularly when you stray into contested disease territory, science can have little to do with getting the right answer. I know you know this. It may just as easily blur into the background with the...

Ok, but I'm still unclear of what you're trying to say. I get that you need eyeballs to see, and neurons, etc, but it's still redundant to say the perception of seeing. And why assume there is an error in the perception process? If you assume that because, say, we can't find any overt structural...

I'm unclear what the difference would be between fatigue and pain, and the perception of fatigue and pain, but the potential genetic role is intriguing. Of course, with ME/CFS it only seems appropriate that we wouldn't be able to demonstrate that role conclusively.

At least partially undone by at least one unfortunate thing re: making sweeping declarations about infections like chronic Lyme, if @Utsikt's report is accurate. I am always wary of ME/CFS allies who seem to fumble an understanding of similarly contested diseases. Of course, we need all the...

The millions who have evidence they have one or the other will be relieved to hear this.

Interesting study that explores RYR1 gene variations and their import to things like muscle weakness and ATP and mitochondrial function, and how these change with age in healthy individuals vs those with channelopathies. RYR1 variations have been tied into ME/CFS before. This study parses down...

I generally look at these gene explanations as a form of victim blaming. Regardless, there is no need for HLA to explain persistence, at least as far as Lyme is concerned. But who knows? Well, perhaps the relentless group of mainstream spirochete sleuths that have viewed HLA as the holy grail...

So is taking in more salt, and I'm equally skeptical of its success as a treatment. Not sure what this has to do with POTS.

Over significant fields of time? Does infection duration factor in? Is the IgG vs IgM consideration a thing with infections that persist? Is this not a gene thing as much as it is a function of chronicity? As an example: syphilis.

Imo, this is a very dangerous declaration. I would suggest the eyes of most of the people who need persuading are of the political sort. Doctors typically trail behind, except for the few trailblazers that first have to endure cross burning..

Agreed. Yet I have to worry about stepping on a doctor's or nurse's toes most times I try to correct a misguided notion. You may not understand it, but neither did I the many times when I naively first tried to enlighten a professional. It's just a reality. We can parse down on symptom...

I cannot speak for most pwME, of course, but I use terms like brain fog because I know most doctors would not understand if I went into specifics, or would misconstrue. It is the medical profession's inability to stay abreast of the patient experience, or indifference to doing so, that I think...