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Genetic mechanisms, brain structures, and peripheral biomarkers mediate the relation between physical frailty and neuropsychiatric disorders Pei-Yang Gao, Yan Fu, Xiao-Yu He, Dan-Dan Zhang, Hao-Chen Chi, Yi-Ming Huang, Zhi-Bo Wang, Wei Zhang, Ya-Nan Ou, Yi-Jun Ge, Jia You, Ling-Zhi Ma, Yi-Xuan...

Military Exposures and Early Menopause: Findings From the Gulf War Era Cohort Study (GWECS) Carolyn J. Gibson, Guichan Cao, Sabra Inslicht, Allison D. Altman, Caitlin E. Haas, Aaron Schneiderman, Erin Dursa [Line breaks added] Objective Traumatic and environmental exposures during military...

The link formatting got messed up. Here's a working link: In which way could Psychiatry and Psychology help investigate ME/CFS (and what exactly is Neuropsychiatry?)–Discussion Thread

S4ME thread: Postorgasmic Illness Syndrome: Insights from Recent Literature on a Rare but Fascinating Disorder, 2025, Wdowiak et al News article linked in above thread: Timeline and symptoms somewhat comparable to PEM.

PsyPost: 'Rare post-orgasm illness causes days-long flu-like symptoms, but research into its cause remains limited' 'A rare and poorly understood condition known as post-orgasmic illness syndrome, or POIS, causes a wide range of flu-like and allergic symptoms following ejaculation. These...

Postorgasmic Illness Syndrome: Insights from Recent Literature on a Rare but Fascinating Disorder Krystian Wdowiak, Agnieszka Maciocha & Julia Wąż [Line breaks added] Abstract Post-orgasmic illness syndrome (POIS) is a rare condition characterised by flu-like and allergic symptoms that...

I pulled all the significant findings, in either males, females, or combined, from the BMI-corrected findings. I did a very quick and dirty search to see which direction they are expected to change with increased BMI. I bolded the ones that were the opposite direction or were a bit more...

Ah, he's pretty much explicitly saying that depression is "all in your head". And his point is that 'omics studies of "all in your head"-diseases find markers in the blood, so the present study's results don't show ME/CFS isn't all in your head.

From the abstract of the Nature paper: There seems to be little to no overlap between significant results in the two papers. By similar results, does he mean they both did 'omics studies?

The Carson comment is just blatantly wrong, so I sent an email to SMC to ask they correct it:

I see. Still, maybe it would have made sense to just try to match the distributions of BMI exactly by excluding as many controls as necessary. There were so many controls that I'm not sure that would have been much of an issue in terms of statistical power. Maybe we should be looking for...

The above mostly seem like markers I'd expect to be associated with high BMI. There was only slightly higher BMI in cases (~1 point for males and ~2 points for females), but with sample sizes this large, could that be enough to make BMI markers significant? They seem to have done some kind of...

Copying the figure showing the results of the replication attempt: Significantly increased in both Alkaline phosphatase glucose hba1c leukocyte count neutrophil count triglyceride/HDL-C ratio triglycerides triglyceride glucose index Significantly decreased in both HDL-C

I'm curious why not? Is it concern about long term harm, or the possibility of a bad trip?

I wonder if any of the findings here are worthy of being added to the thread 'What are the top replicated ME/CFS findings?'. I've only read (most of) the paper and haven't followed up on the cited studies. These seem to be the findings they say have been replicated in greater than two studies...

I think I remember some talk about using DXM, another hallucinogen, as a placebo in psychedelic trials for mental health conditions. It's not perfect because the effects are different, so it requires participants who don't have experience with these drugs. Edit: This paper lists potential...

Figure 1. Timeline of treatments and responses for each patient, aligned at moment of first treatment at pain clinic.

Clinical treatment of cluster headache with the serotonergic indoleamine psychedelics psilocybin and LSD and with ketamine: A case series Jonathan Leighton, Carmen Lau, Aisha Savdo, Livia Granata Background Cluster headache is an excruciating condition for which standard treatments are usually...

The study is both about "CFS" and excluded people with "CFS". Similar issue in another paper from Michael Maes: