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  1. forestglip

    Impacts of the 2024 change in US government on ME/CFS and Long Covid

    It looks like they've updated the report: https://www.whitehouse.gov/maha/ Here's an older version from New York Times (PDF) Examples of references to non-existent papers: 420. Farber, H. J., Wang, G., Guerra, J., & Tsao, K. (2017). Overprescribing of Oral Corticosteroids for Children With...
  2. forestglip

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    https://s4me.info/threads/was-there-a-gap-between-trigger-and-onset-of-your-me-cfs.40505/
  3. forestglip

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    There's this study, but it was studying CF, not CFS: Chronic fatigue and organophosphate pesticides in sheep farming: a retrospective study amongst people reporting to a UK pharmacovigilance scheme (2003, Ann Occup Hyg) There's the link between gulf war illness, which can manifest as ME/CFS...
  4. forestglip

    Forum software update - Forum unavailable weekend 7th to 8th June

    Should this thread be moved to a non-members only forum? There might be people who visit to read but don't log in and would want to know about this.
  5. forestglip

    Forum software update - Forum unavailable weekend 7th to 8th June

    Here is the time that the forum update will start, converted to various timezones, using this website: https://meetingplanner.io/timezone Honolulu, United States (HST) Jun 07, 2025 — 02:00 am Anchorage, United States (AKDT) Jun 07, 2025 — 04:00 am Los Angeles, United States(PDT) Jun 07, 2025 —...
  6. forestglip

    October 2025 IACFS/ME Conference

    From email newsletter: ------ 2025 Virtual Research and Clinical Conference October 22 - 25, 2025 Call for Abstracts Deadline extended: June 11, 2025, 5 PM New York City (USA) EDT time Due to multiple requests, we are re-opening the call for research abstracts for a limited time, from now...
  7. forestglip

    Preprint Mobius: Mixture-Of-Experts Transformer Model in Epigenetics of ME/CFS and Long COVID, 2025, Acharya & Jacoby

    I was emailing with the second author, Derek Jacoby. He is in fact working with Piyush. He says they have just recently presented this paper at the BioSMART conference in Paris, and they hope within the next few weeks that a peer-reviewed version will be published. He confirmed that, though the...
  8. forestglip

    The normal effects of exertion on the body

    Preprint - Circulating Antimicrobial Peptides as Biomarkers of Inflammation and Airway Dysfunction After Marathon Running, 2025, Lingitz et al The antimicrobial peptides Calprotectin and beta defensin 2 were significantly increased in both marathoners and half-marathoners immediately after...
  9. forestglip

    Selin Lab

    Comparison of T-cell Receptor Diversity of people with Myalgic Encephalomyelitis versus controls, 2023, Dibble, Ponting et al
  10. forestglip

    Pathogens associated with triggering ME/CFS - discussion thread

    Thread: Increased risk of chronic fatigue syndrome following infection: a 17-year population-based cohort study, 2023, Chang et al Various antibiotics appeared to decrease risk of the fatiguing conditions. Everything they tested except Clarithromycin. Though the sample size is small for these...
  11. forestglip

    Pathogens associated with triggering ME/CFS - discussion thread

    This might be useful. Though while the thread is about trigger infections, I don't think they were necessarily testing them for pathogens during onset, but later when the condition was established, so I'm not sure if there's a better thread. This correspondence from John Chia and his son Andrew...
  12. forestglip

    Preprint Circulating Antimicrobial Peptides as Biomarkers of Inflammation and Airway Dysfunction After Marathon Running, 2025, Lingitz et al

    They tested a few antimicrobial peptides in sedentary controls, half-marathoners, and marathoners at baseline, immediately after the run, and 2-7 days after the run (only baseline for controls). Two peptides, calprotectin (S100A8/S100A9) and human beta-defensin 2 (hBD-2) were clearly elevated in...
  13. forestglip

    Preprint Circulating Antimicrobial Peptides as Biomarkers of Inflammation and Airway Dysfunction After Marathon Running, 2025, Lingitz et al

    Circulating Antimicrobial Peptides as Biomarkers of Inflammation and Airway Dysfunction After Marathon Running Marie-Therese Lingitz, Hannes Kühtreiber, Lisa Auer, Michael Mildner, Claus G. Krenn, Clemens Aigner, Bernhard Moser, Christine Bekos, Hendrik Jan Ankersmit [Line breaks added]...
  14. forestglip

    Preprint Mobius: Mixture-Of-Experts Transformer Model in Epigenetics of ME/CFS and Long COVID, 2025, Acharya & Jacoby

    I don't think that GitHub page is related, even though they link to it. I think it's just a user named mobius. It includes things related to playstation emulators and Star Wars and has existed for at least 12 years.
  15. forestglip

    Preprint Mobius: Mixture-Of-Experts Transformer Model in Epigenetics of ME/CFS and Long COVID, 2025, Acharya & Jacoby

    I don't think it's the same person based on the photo too: https://theorg.com/org/hack-club/org-chart/piyush-acharya
  16. forestglip

    Preprint Mobius: Mixture-Of-Experts Transformer Model in Epigenetics of ME/CFS and Long COVID, 2025, Acharya & Jacoby

    The lead author, Piyush Acharya, seems to be in high school. A news article says he was in 10th grade in Jan 2024. He apparently started a non-profit called DNanalyzer three years ago. The GitHub page says "Supported by Anthropic. [...] Our impact has been recognized by Y Combinator, the...
  17. forestglip

    Preprint Mobius: Mixture-Of-Experts Transformer Model in Epigenetics of ME/CFS and Long COVID, 2025, Acharya & Jacoby

    There's a whole fancy website showing off the model and recommending clinicians to use it in their practice: https://mobius.dnanalyzer.org/ It includes some findings not included in the preprint:
  18. forestglip

    Preprint Mobius: Mixture-Of-Experts Transformer Model in Epigenetics of ME/CFS and Long COVID, 2025, Acharya & Jacoby

    I have no idea what to do with it, but just noting that it looks like they shared all the raw methylation data for the hundreds of participants (sourced from 14 other studies): https://huggingface.co/datasets/VerisimilitudeX/EpiMECoV
  19. forestglip

    Preprint Mobius: Mixture-Of-Experts Transformer Model in Epigenetics of ME/CFS and Long COVID, 2025, Acharya & Jacoby

    97.06% accuracy is very high. One thing is that all ME/CFS samples were pre-pandemic, so some of the difference between ME/CFS and LC might be related to time of sampling. But to not misclassify any samples between HC and disease is striking. It implies there were virtually no misdiagnoses in...
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