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  1. forestglip

    droracle.ai : What are the recommended treatments for chronic fatigue syndrome?

    It looks like stimulants are both recommended and not recommended.
  2. forestglip

    Amatica Patient-centred chronic disease research

    See discussion of Amatica's analyses related to ROCK1 protein here: Rock1 protein
  3. forestglip

    Rock1 protein

    I can't see this being more useful. We currently can see that the "substantial bulge" is four or so points next to each other now. If they were all squished together on the left side, there'd be a more or less a thin line on the left side, with a bulge still in the same location but where it's...
  4. forestglip

    Rock1 protein

    I'm not really understanding in what way it's misleading. The number of points in the left plot is clearly visible here. I think the difference in cohort sizes would be less clear if the points were squished together.
  5. forestglip

    Deep Sequencing of BCR Heavy Chain Repertoires in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Ryback et al

    Noting that they do say the exact date in Milivojevik/Lipkin 2020:
  6. forestglip

    Open Norway: Study of Daratumumab Injections for Patients with Moderate to Severe Chronic Fatigue Syndrome, 2025

    We've moved some posts about smartwatches to a new thread: Smartwatches for health monitoring
  7. forestglip

    United Kingdom News (including UK wide, England, NI and Wales - see separate thread for news from Scotland)

    BBC: 'Play explores life with a hidden chronic illness' 'YAWN, written and performed by Hollie Christian-Brookes, a former Bath University student, charts the emotional and physical toll of Myalgic Encephalomyelitis (ME), also known as Chronic Fatigue Syndrome (CFS).' 'Having played at the The...
  8. forestglip

    Deep Sequencing of BCR Heavy Chain Repertoires in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Ryback et al

    This thread's study, plus the following two: The first one isn't exactly the same as the other two since they couldn't discriminate between IGHV3-23 and IGHV3-30, and the ME/CFS group seemed to have individuals with both very high and very low amounts of the combination of these gene segments...
  9. forestglip

    Deep Sequencing of BCR Heavy Chain Repertoires in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Ryback et al

    I'm really interested in what is going on behind the scenes with IGHV3-30. Is anything happening? Three studies with a positive result on something so specific feels to me like an "all hands on deck" moment. And there's a way this finding potentially relates to daratumumab. If dara works, it...
  10. forestglip

    Characteristics of 86 families and 142 children diagnosed with Pediatric Condition Falsification in the Netherlands 2025 Worm et al

    It's at least very similar, if not the same thing: Caregiver-Fabricated Illness in a Child: A Manifestation of Child Maltreatment, 2013, Pediatrics
  11. forestglip

    Hypothesis Reassessing Chronic Lyme Disease and Post-Treatment Lyme Disease Syndrome as Focal Infections, 2025, Lakos et al

    Reassessing Chronic Lyme Disease and Post-Treatment Lyme Disease Syndrome as Focal Infections András Lakos, Gyöngyi Nagy, Zoltán Varga, Péter Rásonyi-Kovács, Sándor Hornok [Line breaks added] Abstract The complete clinical spectrum of Lyme borreliosis has been recognized for nearly 50 years...
  12. forestglip

    Deployment-Related Toxic Exposures, Mental Health Problems, and Suicide Outcomes among Gulf War Era U.S. Veterans, 2025, Patel et al

    Deployment-Related Toxic Exposures, Mental Health Problems, and Suicide Outcomes among Gulf War Era U.S. Veterans Tapan A. Patel, Kyle J. Bourassa, Patrick S. Calhoun, Jean C. Beckham, Mary J. Pugh, Nathan A. Kimbrel [Line breaks added] Abstract Exposure to toxins, such as pesticides, smoke...
  13. forestglip

    Open Norway: Study of Daratumumab Injections for Patients with Moderate to Severe Chronic Fatigue Syndrome, 2025

    We've deleted posts about some tweeted data. We generally don't allow discussion of personal health data from identified people without their permission.
  14. forestglip

    Pyridostigmine Improves Hand Grip Strength in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Scheibenbogen et al

    From some cursory research I did previously, it seemed like military got a relatively low dosage:
  15. forestglip

    Trial Report Feasibility and tolerability of dual-target [rTMS] for treatment of [ME/CFS]: An open label pilot study, 2025, Corlier et al

    Feasibility and tolerability of dual-target repetitive transcranial magnetic stimulation (rTMS) for treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): An open label pilot study Juliana Corlier, Hrag Peltekian, Thomas E. Valles, Cole D. Matthews, Doan Ngo, Reza...
  16. forestglip

    Circulating Levels of SMPDL3B Define Metabolic Endophenotypes and Subclinical Kidney Alterations in [ME], 2025, Rostami-Afshari, Moreau+

    Part of the discussion was about how the difference might have been driven by contraceptive use: I think it would have made sense to consider contraceptive use in this paper as well, but I don't see that word mentioned.
  17. forestglip

    Genetics: RABGAP1L

    Linking to the thread for a fibromyalgia GWAS since there was a signal in the same region and they believe it may be related to GPR52: The two relevant loci in DecodeME, showing that there may be a signal in the HTT region in ME/CFS as well (black triangles are locations of top hits from...
  18. forestglip

    The genetic architecture of fibromyalgia across 2.5 million individuals, 2025, Kerrebijnet al.

    More from the paper: As the images I posted above show, there seem to be at least suggestive signals (p<5e-6) at these same two locations in DecodeME. So maybe GPR52 and HTT form an important pathway in ME/CFS as well. Another drug target:
  19. forestglip

    Fibromyalgia and hand diseases: A case-control study, 2025, Magen et al

    They did match by age, so there should be the same proportion of elderly people in the control group.
  20. forestglip

    The gut microbial composition is different in chronic fatigue syndrome than in healthy controls, 2025, Prylińska-Jaśkowiak et al

    The gut microbial composition is different in chronic fatigue syndrome than in healthy controls Monika Prylińska-Jaśkowiak, Hanna Tabisz, Sławomir Kujawski, Beata R. Godlewska, Joanna Słomko, Beata Januszko-Giergielewicz, Modra Murovska, Karl J. Morten, Łukasz Sokołowski & Paweł Zalewski [Line...
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