I can't see this being more useful.
We currently can see that the "substantial bulge" is four or so points next to each other now. If they were all squished together on the left side, there'd be a more or less a thin line on the left side, with a bulge still in the same location but where it's...
I'm not really understanding in what way it's misleading. The number of points in the left plot is clearly visible here. I think the difference in cohort sizes would be less clear if the points were squished together.
BBC: 'Play explores life with a hidden chronic illness'
'YAWN, written and performed by Hollie Christian-Brookes, a former Bath University student, charts the emotional and physical toll of Myalgic Encephalomyelitis (ME), also known as Chronic Fatigue Syndrome (CFS).'
'Having played at the The...
This thread's study, plus the following two:
The first one isn't exactly the same as the other two since they couldn't discriminate between IGHV3-23 and IGHV3-30, and the ME/CFS group seemed to have individuals with both very high and very low amounts of the combination of these gene segments...
I'm really interested in what is going on behind the scenes with IGHV3-30. Is anything happening? Three studies with a positive result on something so specific feels to me like an "all hands on deck" moment.
And there's a way this finding potentially relates to daratumumab. If dara works, it...
Reassessing Chronic Lyme Disease and Post-Treatment Lyme Disease Syndrome as Focal Infections
András Lakos, Gyöngyi Nagy, Zoltán Varga, Péter Rásonyi-Kovács, Sándor Hornok
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Abstract
The complete clinical spectrum of Lyme borreliosis has been recognized for nearly 50 years...
Deployment-Related Toxic Exposures, Mental Health Problems, and Suicide Outcomes among Gulf War Era U.S. Veterans
Tapan A. Patel, Kyle J. Bourassa, Patrick S. Calhoun, Jean C. Beckham, Mary J. Pugh, Nathan A. Kimbrel
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Abstract
Exposure to toxins, such as pesticides, smoke...
We've deleted posts about some tweeted data. We generally don't allow discussion of personal health data from identified people without their permission.
Feasibility and tolerability of dual-target repetitive transcranial magnetic stimulation (rTMS) for treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): An open label pilot study
Juliana Corlier, Hrag Peltekian, Thomas E. Valles, Cole D. Matthews, Doan Ngo, Reza...
Part of the discussion was about how the difference might have been driven by contraceptive use:
I think it would have made sense to consider contraceptive use in this paper as well, but I don't see that word mentioned.
Linking to the thread for a fibromyalgia GWAS since there was a signal in the same region and they believe it may be related to GPR52:
The two relevant loci in DecodeME, showing that there may be a signal in the HTT region in ME/CFS as well (black triangles are locations of top hits from...
More from the paper:
As the images I posted above show, there seem to be at least suggestive signals (p<5e-6) at these same two locations in DecodeME. So maybe GPR52 and HTT form an important pathway in ME/CFS as well.
Another drug target:
The gut microbial composition is different in chronic fatigue syndrome than in healthy controls
Monika Prylińska-Jaśkowiak, Hanna Tabisz, Sławomir Kujawski, Beata R. Godlewska, Joanna Słomko, Beata Januszko-Giergielewicz, Modra Murovska, Karl J. Morten, Łukasz Sokołowski & Paweł Zalewski
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