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Oh what about IGHV3-30? Two or three studies have found small but significant increases in this gene on B cell receptors. I don't even know if making a tracer specifically for a small section of a BCR is possible. But if so, it might point us to where exactly these odd B cells are active...

First is raw scores, so basically the same as figure 3D, but with consistent intervals on the x-axis. Second is absolute change from timepoint 0 (how many points up or down). Third is fold change from timepoint 0 (e.g. doubling the score would be 2). I'm not totally sure what this means and I...

Here's the change as a ratio of each time point to the start of the study. A ratio with the 85-112 timepoint (when the dara was administered) would be kind of misleading because the first dara injection was 5 days into this 28 day range, so the reference point for the start would mostly be data...

I'd say the top four look pretty good. The paper was saying participants 2 (red) and 5 (green) were also responders based on questionnaires, with participant 5 not sustaining the improvement. Participant 2's (red) subjective improvement does seem really close to the other four sustained...

It's kind of hard to make out what's going on in the chart of steps vs. time (fig. 5A) because they all start from a wide variety of baseline steps. So I plotted change in steps from start of study to make it easier to see the timeline of improvement. Each position on the x-axis is an average...

I don't know. It'd be great to have large effect sizes, but the next best thing is at least being significant. Until we have a reason to forget about it, like a study that finds the opposite, I think it's fine to speculate about. Small but significant can still be biologically meaningful. You...

No, it'd be log2(x mg/dL) = [number on y axis] So reverse the calculation. To go from the y axis to the real measurement, you do 2^number. So a value of 8 on the chart equals 2^8=256 mg/dL. I think it's normally done when the data is skewed. Taking the log makes it more normally distributed...

It feels like the abstract is lacking in detail. What do they mean by "neuronal activity" or "metabolic information"?

Could you explain more about why it's implausible?

Why would the body keep thinking there are toxins?

Ok thanks. How did you select traits to highlight? For example, BTN3A2 has 97 traits, some with even lower p values than some of the traits in your table, such as height or teeth issues.

Can you give more detail for how you used to decodeme data to get these lists of traits? Search for genes? Variants? Ranges?

I wasn't sure what "blue space" meant. Wikipedia

Defining a long COVID ‘expotype’ within the P4O2 COVID-19 study J.C.S. Holtjer, L. Houweling, L.D. Bloemsma, M.E.B. Cornelissen, A.H. Maitland-Van der Zee, L. Portengen, S. Kakhaia, R.C.H. Vermeulen, G.S. Downward, the P4O2 consortium [Line breaks added] Highlights • First study to...

Now published: Global Prevalence of Long COVID, Its Subtypes, and Risk Factors: An Updated Systematic Review and Meta-analysis Yiren Hou, Tian Gu, Zhouchi Ni, Xu Shi, Megan L Ranney, Bhramar Mukherjee [Line breaks added] Background This mega-systematic review evaluated the global prevalence...

Uncorrected proof published on PLOS Medicine: Effect of Paxlovid treatment during acute COVID-19 on Long COVID onset: An EHR-based target trial emulation from the N3C and RECOVER consortia [Line breaks added] Background Preventing and treating post-acute sequelae of SARS-CoV-2 infection...

The following newly released thesis looks like it might be the same study, though the details aren't exactly the same. Thesis Identifying the Neurobiological Substrates of Gulf War Illness, 2025, Jones

I think this might be the same study as the trial registration in this thread, though the details look a little different. Assessing Neuroinflammation in Gulf War Illness Using Magnetic Resonance Spectroscopy, Younger

Identifying the Neurobiological Substrates of Gulf War Illness by Chloe Jones Jarred Younger, Committee Chair; Adam Goodman; Maxine Krengel; Virendra Mishra; Robert Sorge [Line breaks added] Abstract Gulf War Illness (GWI) affects approximately 30% of veterans who served in the 1991 Persian...

Studies from the first few pages of results on Google Scholar (and one found as a citation) related to NKT cells in people with ME/CFS: - Abnormal T-Cell Activation And Cytotoxic T-Cell Frequency Discriminates Symptom Severity In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025...