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I'd call it a smoking gun, unless otherwise proven. Which is precisely why compliance measures such as actigraphy are needed. Without them the results are ambiguous.

Is there an alternative link? Increasingly unkeen on Facebook.

I have not forgotten that appalling little chapter. Lloyd and van de Meer still owe grovelling apologies for it.

Now this is interesting. I have long wondered if the extra-cellular matrix was playing a role.

I would prefer doctors to simply learn to say: 'Sorry, we don't have an explanation or specific treatment. We will do what we can to help relieve symptoms, and otherwise support you.' Some do. But most don't. Or aren't allowed to.

We are past the point where any significant player, with any significant responsibilities and obligations, can be allowed to claim ignorance of the basic facts and disputes. There have been more than enough warnings flags, for at least several years (and arguably a lot longer than that), to...

I fear this patient is suffering a terminal case of projection.

It is their utter certainty bout their 'explanation', from the very start, that is appalling and terrifying. The less they have, they more certain they become. And the more harm they do.

This is a good example of how Wessely can be caught out with his own words (in effect, in this instance). He is very happy to take the credit for it when he thinks it is going well. But runs a million miles from taking any of the blame when it goes arse up. In WesselyWorld it is always the...

Correct. How long did it take for the truth about the Hillsborough stadium disaster to be allowed to be told? Nearly 30 years, and that was a fairly straightforward issue compared to ME.

Generally the legal and bureaucratic view too. No formal record? Didn't happen. Oops. :D

That would be evidence for PEM, and hence perhaps not so surprising.

Accountability always seems 'extreme' to those wishing to avoid it.

"The reanalysis is misleading and designed to yield the desired result." You, sir, are a contemptible hypocrite, scoundrel, and coward.

Effective treatments basically sell themselves. Vaccines became hugely popular when parents saw how many vaccinated children weren't dying. (And started becoming unpopular a couple of generations later when parents were not seeing how many unvaccinated children were dying, because vaccines had...

They simply cannot face the possibility that their beautiful little idea is completely wrong, and doing serious harm.

+1

Thank you to all the letter writers.

This is an important message we need to get out about PACE in particular, but also any other similarly structured trials: they are basically an exercise in maximising known biases (confounders) in psycho-behavioural trials, and then simply relabeling any 'positive' results as a therapeutic benefit.

This is how to beat Wessely: use his own words against him.