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Yes, this feels like quite a step forward. A lot of the possibilities were written up rather more positively than I think is warranted though, although I understand that the purpose of attracting interest requires some hopeful statements. For example this one for NADH and CoQ10: my...

It was a fairly helpful interview, in terms of increasing public understanding of the illness. Dr Vallings does refer to the illness as CFS/ME or Chronic fatigue syndrome which is slightly annoying. She said that there's no reason to think that Long Covid is not a post-viral fatigue syndrome...

https://www.healthrising.org/blog/2021/02/01/garner-recovery-long-covid-recovery-story/ Cort Johnson has written about Garner's recovery. Cort does not appear to have read Garner's previous blogs (edit - and facebook posts), as he does not appear to know that Garner was attempting to run long...

I know that's what Swan is doing. But, he isn't the only person running the show these days, it seems. It is progress, even if it is of the 'water on stone' sort.

:) That does look like progress.

Sorry to hear about the relapse AWNTY. I don't have a SPO2 meter, but I was thinking of the tendency of my hands to go numb when elevated as I read this thread. It happened a lot to me and my two children in the first year we became sick, and it happens these days when I've overdone it. It's...

Notwithstanding this, (that PEM is fundamental to a definition of ME/CFS), I have been wondering if ME/CFS symptoms are a particular subset of possible symptoms arising from related processes during and after an infection. One of the prompts for the wondering is the case of chikungunya on...

I think the name used for the disease in this 'fully revised edition' - 'Chronic Fatigue Syndrome/ME' - is a good indicator of the likely content. Sort of right, but a bit out of date, and with more than a touch of BPS. Assuming it's like Dr Vallings' previous books, people can get better, and...

I've sent a short note to Tegan Taylor at the ABC, to add to her pile of responses. Perhaps others could too - not concentrating on past problems at the ABC, but noting authorities around the world now recognise that psychologically based therapies don't fix ME/CFS. And mentioning the effort...

An article this morning from Radio NZ - mentioned a Long Covid facebook group and research plans Link here:Possibility of ME or PVFS after COVID-19, Long Covid

A pretty good New Zealand article (audio or transcript) https://www.rnz.co.nz/national/programmes/first-up/audio/2018781716/covid-long-haulers-fighting-to-be-heard

A reliable source who had the relevant mushrooms growing in their back garden, and tried them, several times, found no change in ME/CFS symptoms. With my 'mother' hat on, I'd say that causing 'functional connections in the brain to stop working as before and new connections to be formed'...

It's nice that the researchers seemed to end up understanding that PEM is a fundamental symptom of ME/CFS. It's a shame they didn't know that before choosing to spend their time on a study characterising CFS. No, 'These results question the clinical usefulness of searching for CFS subgroups...

Thanks Snow Leopard, link added. Here's a recent overview of studies of the pathology, some in humans. Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis, 2020, L'Herondelle et al

The paper mentions voltage-gated sodium channels (Nav) as the primary target of the toxins. Downstream effects include an increase in intracellular calcium concentration by various mean, including calcium influx through transient receptor potential (TRP) channels. A blood transcriptomic study...

Killian L’Herondelle,1 Matthieu Talagas,1,2 Olivier Mignen,3Laurent Misery,1,2 and Raphaele Le Garrec1,* (French researchers) Abstract Ciguatera fish poisoning (CFP), the most prevalent seafood poisoning worldwide, is caused by the consumption of tropical and subtropical fish contaminated with...

@Snow Leopard, have you seen this? In your cornucopia of papers, you seem to be focusing on some of the molecules and processes that are thought to be important in long term ciguatera. There are quite a lot of recent papers on the pathology of ciguatera, as, with climate change, it seems to...

Good try, but I don't think that was the paper I was thinking of. I'll try to find it.

From this 2018 study Background on ciguatera: Long-term symptoms with similarities to ME/CFS (there are other accounts of symptoms that sound very similar indeed): They think they have identified a mechanism for 'long-lasting neurological changes': On upregulated ephrins and axon...