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This on CD4 from the pathway analysis HLA-DRA also popped up in Fig 4 although I’m not sure of the significance. Some quotes on the potential for specific subgroups And

Why? In my mind seeing if they can reproduce the results, albeit while resolving the concerns raised, is exactly what we need.

There’s definitely lots of the usual narrative of inflammation, neuro-inflammation, dysregulated immune states, etc. It has the feel of one of those papers which is trying too hard in parts and perhaps doesn’t try hard enough in others leaving me questioning the findings the more I read...

Thanks. Really useful to have your thoughts and look forward to others too. There seems to be a lot of the usual framing throughout but wondered if there may be something there nevertheless. But am having difficulty getting my head around it all and am not sure if that is the paper, the...

Understood. My question is still if this can be replicated will it tell us something useful about what is going on? It seems so from the pathways section of the paper? If you’re also not comfortable being drawn on that sort of speculation I get it. It just seems pretty relevant here as there...

I agree. But if this does turn out to be accurate it potentially does tell us something doesn’t it? At least that’s what the pathways section of the paper seems to indicate? And why I asked Chris about it, although completely understand his response you can’t blame me for trying :) Of course it...

Understood. Thanks @Chris Ponting @DMissa I’m not sure it is, the tweet says But I cannot see this claim in the paper and the criteria for the UK ME/CFS Biobank are stated as We have in the past trusted the Biobank sampling. The other concerns @Chris Ponting raises seem more relevant

Thanks for this @Chris Ponting I was just about to share your comments. Looks some we need some caution then. Would be great if we could see this replicated of course. Did you have any thoughts on the signalling pathways they identified and if this fits in with DecodeME at all?

Precision Life have the data and are into the idea of subgroups. Difficult for us to interpret given their analysis methods are a black box and they don’t seem great at communicating with us. But if they show some subgroups with the same data and can explain and perhaps tie it to the same...

Wow, formal language and management speak but brutal. My interpretation: Leadership and role clarity - There is no leadership and there are conflicts of interest Governance structures - The processes in place to do the basics any governance structure should are not present Member engagement -...

Sorry I haven’t caught up with the whole discussion but have been through the overview and wanted to thank @PeterW for the obvious work, time and effort spent on this. Thank you. You’d make a good trustee!

“ The survey will take approximately 10–15 minutes” Well that’s wildly incorrect to start. There are 43 questions. How many of us can read, process, respond to 3-4 questions a minute. A healthy person maybe but… I wish more researchers got the basics right

Yeah, the problem here, as is so often the case, is it appears you have some grifters trying to make money. I suspect they won’t

This is part of special issue of the Journal of Clinical Medicine with the title “The Rise of Mitochondria in Medicine” which contains reviews like this but also research linking the mitochondria with innate immunity more widely as well as in specific diseases...

Metabolism and Innate Immunity Meet at the Mitochondria Bahat, A., MacVicar, T., & Langer, T Abstract Mitochondria are master regulators of metabolism and have emerged as key signalling organelles of the innate immune system. Each mitochondrion harbours potent agonists of inflammation...

The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders Missiroli S, Genovese I, Perrone M, Vezzani B, Vitto VAM, Giorgi C Abstract The main features that are commonly attributed to mitochondria consist of the regulation of cell proliferation, ATP generation, cell...

I can understand the negative feelings some have given all the history. I’ll be honest, my first reaction was more ‘wtf’ than anything. But others here raise some really good points. And I want to echo that it’s important we get senior and influential people from across all political wings on...

I’d never heard of this, it appears to be from a US based company called The Deep LLC https://finance.yahoo.com/news/thedeep-llc-artificial-intelligence-ai-184200084.html

Sounds like the David Strain created one released a month ago and already discussed in this thread? Interesting it’s being publicised by the NHS now though, I wonder if it’s been updated at all following feedback? The modified date for the session is now yesterday.

In my head it was more localised interferon only, with the EV or free mitochondria being the routes for this to travel between separate sites. Precisely because we don’t have or see systemic interferon levels raised. One of the biggest flaws is probably… if these exported and damaged/interferon...